Acriflavine HCl is a type of dye commonly used as a topical antiseptic for skin infections. Acriflavine is freely soluble in aqueous solution.
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| Mechanism of Action | Acriflavine toxicity arises from its ability to bind to and intercalate DNA. DNA intercalation leads to numerous errors which have a lethal effect on targeted organisms. |
| Microbiology Applications | Acriflavine has been used in RNA fluorescent labeling applications by RNA hydrolysis using HCl. |
| Cancer Applications | Acriflavine has been shown to inhibit HIF-1, a heterodimeric transcription factor which responds to hypoxia and facilitates further cancer progress. Acriflavine prevents dimerization of HIF-1 to prevent its role in cancer growth. |
| Molecular Formula | C13H11N3 and C14H14N3 •HCl |
| References | Kawai, Mako, and Et Al. "Mechanisms of Action of Acriflavine: Electron Microscopic Study of Cell Wall Changes Induced in Staphylococcus Aureus by Acriflavine."Microbiology and Immunology (2009): 481-86. Onlinelibrary.com. Web. 29 Aug. 2012. Levinson, J. W. "Fluorescent Labeling of Fragments of High Molecular Weight RNA." Energy Citations. N.p., n.d. Web. 18 Sept. 2012. Lee, K., and Et Al. "Acriflavine Inhibits HIF-1 Dimerization, Tumor Growth, and Vascularization." Proceedings of the National Academy of Sciences of the United States of America 106.42 (2009): 17910-7915. Pnas.org. 20 Oct. 2009. Web. 20 Sept. 2012. |
| MIC | Escherichia coli| 2 - 128|| Klebsiella pneumonia| 128 - 512|| Staphylococcus aureus| 3.13 - 50|| |
