Actinonin is a metabolite of Streptomyces roseoplallidus and other Streptomyces species, first reported in Nature in 1962. Actinonin is a bacteriostatic agent with activity against Gram-positive and fastidious Gram-negative microorganisms. Actinonin inhibits MMP, aminopeptidases and peptide deformylase. Actinonin inhibits growth of NB4 and HL60 human cell lines and AKR mouse leukemia cells in vitro. Its effects on apoptosis, growth inhibition, and therapeutic effects in vivo are not likely to be mediated by CD13/APN.
| Molecular Formula | C19H35N3O5 |
| References |
Chen DZ et al (2000) Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase Inhibitor. Biochemistry 39:125 Gordon JJ et al (1962) Actinonin: an antibiotic substance produced by an actinomycete. Nature 195:701 Sina A et al (2009) Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation. Cancer Lett. 279:171 |