SKU: A203  / 
    CAS Number: 641-38-3

    Alternariol

    $154.35 - $540.23

    Alternariol is a mycotoxin produced by Alternaria and is often found as a contaminant in fruit and small grain cereal products.  Structurally, it is characterized as a dibenzopyranone.  It can be used as an analytical standard.  The product is soluble in methanol or DMSO.

    Molecular Formula  C14H10O5
    Spectrum Alternariol is active against fungi.
    Eukaryotic Cell Culture Applications Human colon carcinoma cells were used to elucidate the cell death mode and pathways triggered by Alternariol.  The mycotoxin induced apoptosis and thus cell viability.  It was mediated via a motochondria-dependent pathway.  It does not target this organelle directly; its cytotoxicity is mediated by the activation of the mitochondrial pathway of apoptosis (Bensassi F et al, 2012).
    Mechanism of Action Alternariol damages DNA and causes base oxidations and strand breaks, and phosphorylation (activation) of histone H2A and check point kinase-1 and 2 (Chk-1/2).  Alternariol-induced DNA damage and resulting transcriptional changes in p21, MDM2 and Cyclin B contribute to a reduction of cell proliferation.  
    References
    Asam S et al (2011)  Precise determination of the Alternaria mycotoxins Alternariol and Alternariol monomethyl ether in cereal, fruit and vegetable products using stable isotope dilution assays.  Mycotoxin Res. 27(1):23-28
     
    Bensassi F et al (2012)  Cell death induced by the Alternaria mycotoxin Alternariol. Toxicol. In Vitro 26(6):915-923
     
    Solhaug A et al (2012)  Mechanisms involved in alternariol-induced cell cycle arrest. Mutat. Res. 738-739:1-11  PMID 23031795