SKU: A210  / 
    CAS Number: 486-89-5

    Anagyrine

    $233.70 - $817.96

    Anagyrine is a teratogenic quinolizidine alkaloid found in Lupinus sp. which undergoes metabolism to a piperidine that causes crooked calf syndrome. Anagyrine, but not lupanine or sparteine, directly desensitize nicotinic acetylcholine receptors (nAChR) in a cell culture model. Anagyrine is reported to have antiarrhythmic, tachycardic, diuretic and purgative properties. Extracts containing anagyrine have antifungal activity.

    Molecular Formula  C15H20N2O
    References

    Green BT et al (2017)  Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle. Green Res. Vet. Sci. 115:195

    Handani EN et al (2016)  Antifungal activity of the alkaloids extracts from aerial parts of Retama monosperma. Res. J. Pharm. Biol. Chem Sci. 7:965

    Keeler RF et al (1976)  Lupin alkaloids from teratogenic and nonteratogenic lupins. IV. Concentration of total alkaloids, individual major alkaloids, and the teratogen anagyrine as a function of plant part and stage of growth and their relationship to crooked calf disease.  J. Tox. Env. Health 1:899