Anagyrine is a teratogenic quinolizidine alkaloid found in Lupinus sp. which undergoes metabolism to a piperidine that causes crooked calf syndrome. Anagyrine, but not lupanine or sparteine, directly desensitize nicotinic acetylcholine receptors (nAChR) in a cell culture model. Anagyrine is reported to have antiarrhythmic, tachycardic, diuretic and purgative properties. Extracts containing anagyrine have antifungal activity.
| Molecular Formula | C15H20N2O |
| References |
Green BT et al (2017) Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle. Green Res. Vet. Sci. 115:195 Handani EN et al (2016) Antifungal activity of the alkaloids extracts from aerial parts of Retama monosperma. Res. J. Pharm. Biol. Chem Sci. 7:965 Keeler RF et al (1976) Lupin alkaloids from teratogenic and nonteratogenic lupins. IV. Concentration of total alkaloids, individual major alkaloids, and the teratogen anagyrine as a function of plant part and stage of growth and their relationship to crooked calf disease. J. Tox. Env. Health 1:899 |
