Anguinomycin A is a polyketide natural product and analog of Leptomycin B, an inhibitor of protein nuclear export. It is isolated from Streptomyces spp., and displays anti-cancer activity. Anguinomycins B, C and D are also members of the Leptomycin family.
Anguinomycin A is soluble in ethanol and methanol but unstable in DMSO.
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Bonazzi S et al (2010) Anguinomycins and derivatives: Total syntheses, modeling, and biological evaluation of the inhibition of nucleocytoplasmic transport. J. Am. Chem. Soc. 132 (4):1432-1442
Hayakawa Y, Adachi K and Komeshima N (1987) New antitumor antibiotics, Anguinomycins A and B. J. Antibiot. 40:1349
Hayakawa Y et al (1995) Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells. J. Antibiot. 48:954