SKU: A122  / 
    CAS Number: 111278-01-4

    Anguinomycin A

    $355.57 - $1,244.50

    Anguinomycin A is a polyketide natural product and analog of Leptomycin B, an inhibitor of protein nuclear export.  It is isolated from Streptomyces spp., and displays anti-cancer activity.  Anguinomycins B, C and D are also members of the Leptomycin family. 

    Anguinomycin A is soluble in ethanol and methanol but unstable in DMSO.

    We also offer:

    • Leptomycin A (L020)
    • Leptomycin B (L004)
    • Kazusamycin A (K018)
    • Kazusamycin B (K019)
    References

    Bonazzi S et al (2010)  Anguinomycins and derivatives: Total syntheses, modeling, and biological evaluation of the inhibition of nucleocytoplasmic transport.  J. Am. Chem. Soc. 132 (4):1432-1442

    Hayakawa Y, Adachi K and Komeshima N (1987)  New antitumor antibiotics, Anguinomycins A and B. J. Antibiot. 40:1349

    Hayakawa Y et al (1995)  Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells. J. Antibiot. 48:954