Anidulafungin is a semi-synthetic echinocandin derivative and antifungal effective against Candida spp. Anidulafungin inhibits fungal cell wall synthesis. It is useful in pharmacotherapy and cell culture research applications.
Anidulafungin is slightly soluble in DMSO but practically insoluble in water.
|Mechanism of Action||Anidulafungin inhibits the enzyme (1→3)-β-D-glucan synthase, which is important in fungal cell wall synthesis. The enzyme is not found in mammalian systems.|
|Spectrum||Anidulafungin is active against Candida and Aspergillus spp.|
|Eukaryotic Cell Culture Applications||
Since the compound selectively targets fungal cells and does not exhibit cytotoxicity to mammalian cells in vitro (Harris and Coote, 2010), it is useful in cell culture to combat Candida and Aspergillus spp.
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Salas V et al (2011) Anidulafungin in treatment of experimental invasive infection by: In vitro activity, (1-->3)-beta-D-glucan and mannan serum levels, histopathological findings, and in vivo efficacy. Antimicrob. Agents Chemother. 55 (11):4985-4989 PMID 21844324
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