Anidulafungin is a semi-synthetic echinocandin derivative and antifungal effective against Candida spp. Anidulafungin inhibits fungal cell wall synthesis. It is useful in pharmacotherapy and cell culture research applications.
Anidulafungin is slightly soluble in DMSO but practically insoluble in water.
|Mechanism of Action||Anidulafungin inhibits the enzyme (1→3)-β-D-glucan synthase, which is important in fungal cell wall synthesis. The enzyme is not found in mammalian systems.|
|Spectrum||Anidulafungin is active against Candida and Aspergillus spp.|
|Eukaryotic Cell Culture Applications|| |
Since the compound selectively targets fungal cells and does not exhibit cytotoxicity to mammalian cells in vitro (Harris and Coote, 2010), it is useful in cell culture to combat Candida and Aspergillus spp.
Harris MR and Coote PJ (2010) Combination of caspofungin or Anidulafungin with antimicrobial peptides results in potent synergistic killing of Candida albicans and Candida glabrata in vitro. Int. J. Antimicrob. Agents 35(4):347-356 PMID 20106636
Odds, FC, Brown AJ, Gow NA (2003) Antifungal Agents: Mechanisms of action. Trends Microbiol.11(6): 272-279 PMID 12823944
Patil A and Majumdar S (2017) Echinocandins in antifungal pharmacotherapy. J Pharm. Pharmacol. 69(12):1635-1660 PMID 28744860
Pfaller, M A et al. In vitro activities of Anidulafungin against more than 2,500 clinical isolates of Candida spp, including 315 isolates resistant to fluconazole J. Clinical Microbiol. 43(11):5425-5427
Salas V et al (2011) Anidulafungin in treatment of experimental invasive infection by: In vitro activity, (1-->3)-beta-D-glucan and mannan serum levels, histopathological findings, and in vivo efficacy. Antimicrob. Agents Chemother. 55 (11):4985-4989 PMID 21844324
Vazquez, JA and Sobel JD (2006) Anidulafungin: A novel echinocandin. Clin. Infect. Dis. 43(2):215-222 PMID 16779750