Arbekacin Sulfate (syn: Habekacin Sulfate) is a semisynthetic aminoglycoside antibiotic derived from kanamycin. It was discovered in 1972 orginally synthetized from dibekacin in 1973 (Hamao Umezawa). Its general structure is characterized by two or more aminosugars linked by glycosidic bonds to an aminocyclitol scaffold. Arbekacin is not inactivated by aminoglycoside-inactivating enzymes and shows concentration-dependent effects. Aminoglycoside-induced nephrotoxicity and ototoxicity is not well understood. Understanding the mechanisms of toxicity at the cellular/subcellular level may help in discovery of high-efficacy and low-toxicity aminoglycosides.
Arbekacin Sulfate is very soluble in water.
