SKU: A017  / 
    CAS Number: 78110-38-0

    Aztreonam

    $101.12 - $161.14

    Aztreonam is a ë_-lactam antibiotic originally isolated from Chromobacterium violaceum. It is categorized as a monobactam as it contains a single ë_-lactam ring instead of the fused ë_-lactam and thiazolidine rings found in generic ë_-lactams.  Due to its  unique structure, Aztreonam is not typically inactivated by ë_-lactamases. Aztreonam is used to combat Gram-negative bacteria in microbiology, cancer therapy, and plant tissue culture.  It is insoluble in water but is soluble in ethanol (20 mg/ml), DMSO (20 mg/ml) and DMF (30 mg/ml).

    TOKU-E offers 2 forms of Aztreonam:

    Mechanism of Actionβ-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
    SpectrumAztreonam is effective against Gram-negative bacteria.
    Microbiology ApplicationsAztreonam is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against negative microbial isolates. Aztreonam has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Pseudomonas aeruginosa ≤0.12 µg/mL - >16 µg/mL
    • Proteus mirabilis ≤0.12 µg/mL - >16 µg/mL
    • For a complete list of aztreonam MIC values, click here.
    Plant Biology ApplicationsAztreonam is a broad-spectrum antibiotic commonly used in plant tissue culture to control bacterial contamination from Gram-negative species.
    Cancer ApplicationsAztreonam was effective as the single active antibiotic in the treatment of Gram-negative infections in neutropenic patients; however, it must be used in combination with another antibiotic to provide Gram-positive coverage.
    Molecular FormulaC13H17N5O8S2
    Solubilityethanol (20 mg/ml), DMSO (20 mg/ml) and DMF (30 mg/ml).
    References

    Jones PG et al (1986) Aztreonam therapy in neutropenic patients with cancer. Am. J. Med. 81(2):243-248. PMID 3526885

    Moreau-Marquis S, Coutemarsh B, Stanton BA (2015) Combination of hypothiocyanite and lactoferrin (ALX-109) enhances the ability of tobramycin and aztreonam to eliminate biofilms growing on cystic fibrosis airway epithelial cells. J. Antimicrob. Chemother 70(1):160-166. PMID 25213272

    Pitout JD, Sanders CC, Sanders WE (1997) Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am. J. Med. 1997; 103(1):51-59 PMID 9236486

    MICBacteroides fragilis| 2 - 128|| Borrelia burgdorferi S.L.| 2 - >64|| Burkholderia cepacia| 4 - >512|| Citrobacter amalonaticus| ≤0.12 - >64|| Citrobacter braakii| ≤0.12 - >64|| Citrobacter diversus| 0.03 - >128|| Citrobacter farmeri| ≤0.12 - >64|| Citrobacter freundii| 0.015 - >128|| Citrobacter koseri| ≤0.12 - >16|| Citrobacter spp.| ≤0.12 - >64|| Citrobacter werkmanii | >64|| Enterobacter aerogenes| ≤0.12 - >128|| Enterobacter agglomerans| 0.125 - >128|| Enterobacter amnigenus| ≤0.12 - >64|| Enterobacter asburiae| ≤0.12 - >64|| Enterobacter cancerogenus| ≤0.12 - >16|| Enterobacter cloacae| 0.06 - >128|| Enterobacter gergoviae| ≤0.12 - >16|| Enterobacter hormaechei| ≤0.12 - >16|| Enterobacter intermedius| 0.12 - >64|| Enterobacter sakazakii| 0.06 - 64|| Enterobacter spp.| ≤0.12 - >16|| Enterobacter taylorae| ≤0.12 - >16|| Enterobacteriaceae| 0.004 - 256|| Enterococcus faecalis| ≥128|| Escherichia coli| 0.03 - >128|| Haemophilus spp.| 0.015 - 2|| Hafnia alvei| ≤1|| Helicobacter pylori| 4 - 8|| Klebsiella ornithinolytica| ≤0.12 - >16|| Klebsiella ozaenae| ≤0.12 - >16|| Klebsiella pneumonia| 0.008 - >256|| Klebsiella rhinoscleromatis| ≤1|| Klebsiella spp.| ≤0.12 - >16|| Klebsiella terrigena| ≤0.12 - >16|| Lactobacillus acidophilus| >100 || Lactobacillus gasseri| 100|| Lactobacillus johnsonii| >100 || Lactobacillus paracasei| 100|| Lactobacillus salivarius| >100|| Morganella morganii| 0.004 - 32|| Neisseria spp.| 0.015 - 259|| Ochrobactrum anthropi| ≥128|| Pasteurella multocida| 0.015 - 128|| Plesiomonas shigelloides| 0.015 - 128|| Proteae spp.| ≤0.12 - >16|| Proteus mirabilis| 0.015 - >16|| Proteus penneri| 0.06 - ≤1|| Proteus rettgeri| 0.004 - 1|| Proteus vulgaris| 0.004 - >64|| Providencia alcalifaciens| 0.004 - 1|| Providencia rettgeri| ≤0.125 - 1|| Providencia stuartii| 0.004 - 4|| Pseudomonas aeruginosa| ≤0.12 - 1024|| Pseudomonas maltophilia| >8 - >32|| Pseudomonas spp.| 5 - 128|| Ralstonia pickettii| 128|| Salmonella| ≤0.12 - >16|| Salmonella agona| ≤0.12 - >16|| Salmonella arizonae| ≤0.12 - >16|| Salmonella bareilly| ≤0.12 - >16|| Salmonella enterica| ≤0.12 - >16|| Salmonella enteritidis| 0.03 - >16|| Salmonella hadar| ≤0.12 - >16|| Salmonella heidelberg| ≤0.12 - >16|| Salmonella infantis| ≤0.12 - >16|| Salmonella litchfield| ≤0.12 - >16|| Salmonella Montevideo| ≤0.12 - >16|| Salmonella muenchen| ≤0.12 - >16|| Salmonella Newport| ≤0.12 - >16|| Salmonella panama| ≤0.12 - >16|| Salmonella Paratyphi| ≤0.12 - >16|| Salmonella schwarzengrund| ≤0.12 - >16|| Salmonella spp.| ≤0.12 - >16|| Salmonella stanley| ≤0.12 - >16|| Salmonella stpaul| ≤0.12 - >16|| Salmonella thompson| ≤0.12 - >16|| Salmonella typhi| 0.03 - >16|| Salmonella typhimurium| ≤0.12 - >16|| Salmonella virchow| ≤0.12 - >16|| Serratia fonticola| ≤0.12 - 32|| Serratia liquefaciens| ≤0.12 - >16|| Serratia marcescens| 0.06 - >64|| Serratia odorifera| ≤0.12 - >16|| Serratia plymuthica| ≤0.12 - >16|| Serratia rubidaea| ≤0.12 - >16|| Serratia spp.| ≤0.12 - >16|| Shigella boydii| ≤0.12 - 0.25|| Shigella dysenteriae| ≤0.12 - 0.25|| Shigella flexneri| 0.03 - 1|| Shigella sonnei| 0.03 - 1|| Shigella spp.| ≤0.12 - 0.25|| Shingella dysenteriae| 0.03 - 1|| Staphylococci| 32 - >128|| Staphylococcus aureus| 8 - >128|| Staphylococcus epidermidis| 8 - 32|| Staphylococcus haemolyticus| >32|| Staphylococcus saprophyticus| 32|| Stenotrophomonas maltophilia| >32 - 1024|| Streptococci spp.| 0.5 - 2|| Streptococcus agalactiae| ≥128|| Streptococcus pyogenes| 8 - ≥128|| Xanthomonas maltophilia| >128|| Yersinia enterocolitica| 0.015 - 128||