Bactenecin is a cyclic, 12 amino acid antimicrobial peptide (AMP) with antibacterial activity against Gram-negative and some Gram-positive bacteria.
|Mechanism of Action||Bactenecin inhibits protein synthesis by binding to bacterial ribosomes.|
|Spectrum||Bactenecin is active against Gram-negative bacteria.|
|References||Gagnon, Matthieu G., Raktim N. Roy, Ivan B. Lomakin, Tanja Florin, Alexander S. Mankin, and Thomas A. Steitz. "Structures of Proline-rich Peptides Bound to the Ribosome Reveal a Common Mechanism of Protein Synthesis Inhibition." Nucleic Acids Res Nucleic Acids Research (2016)|