Beauveriolides are 13-membered cyclodepsipeptides isolated from Beauveria sp. Beauveriolide III inhibits acyl-CoA:cholesterol acyltransferase (ACAT) to block the synthesis of cholesteryl ester, leading to a reduction of lipid droplets in macrophages. Beauverolide III is more potent against ACAT1 than ACAT2 (IC50 5.5 vs. > 20 µM, respectively). Beauveriolide III is antiatherogenic activity in mouse models.
| Molecular Formula | C27H41N3O5 |
| References |
Ohshiro T et al (2006) Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers. J. Org. Chem. 71:7643 Oshiro T et al (2009) The selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA : cholesterol acyltransferase. Chem. Pharm. Bull. 57:377 Tomoda H and Doi T (2008) Discovery and combinatorial synthesis of fungal metabolites beauveriolides, novel antiatherosclerotic agents. Acc. Chem. Res. 41:32 |
