Biapenem is a broad-spectrum carbapenem antibiotic with activity against Gram-positive and Gram-negative bacteria. It is useful for pathogens causing intra-abdominal, lower respiratory, and urinary tract infections. It is highly resistant to most types of B-lactamases from both aerobes and anaerobes.
|Mechanism of Action||Biapanem has a similar structure and activity to imipenem but has a methyl group in the 1-beta position. Addition of the methyl group confers resistance to human renal dehydropeptidase-I (DHP-1).|
|Spectrum||Gram-positive, Gram-negative bacteria, both aerobic and anaerobic|
|Microbiology Applications||The in vitro and in vivo activity of Biapenem was compared to imipenem, meropenem and others, against 441 anaerobes. It had activity comparable to imipenem and meropenem against all groups of anaerobes with MICs for 90% strains tested of 0.06 to 2 µg/ml and 98.6% of strains at ≤ 1 µg/ml, indicating excellent performance against anaerobic bacteria. It is active against B. capillosus, Prevotella, Clostridum, and Eubacterium strains. Exceptions include type I, chromosomally mediated β-lactamases from aerobic, Gram-negative bacilli, and the metallo-containing β-lactamases of anaerobes. (Tsuji et al, 1998).|
To review additional MICs for Biapenem from the Antimicrobial Database, click here.
|References||Perry CM and Ibbotson T (2002) Biapenem. Drugs 62(15):2221-2234 PMID 12381221 Aldridge KE, Morice N and Schiro DD (1994) In vitro activity of biapenem (L-627), a new carbapenem, against anaerobes. Antimicrob. Agents Chemother. 38(4):889-93 PMID 8031067 Masakatsu Tsuji, Yoshikazu Ishii, Akira Ohno, Shuichi Miyazaki, and Keizo Yamaguchi 1998. In Vitro and In Vivo Antibacterial Activities of S-4661, a New Carbapenem Antimicrobial Agents and Chemotherapy Vol. 42, No. 1, p. 94–99 PMID 9449267 Singh BK and Macdonald CA (2010) Drug discovery form uncultivable microorganisms. Drug Disc. Today 15(17):792-799|