SKU: B050  / 
    CAS Number: 866022-28-8

    Bischloroanthrabenzoxocinone

    $277.35 - $970.71
    Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC50 values of 11.4 and 35.3 µg/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. FASII is essential to bacterial cell viability and is a promising target for the development of novel antibiotics.

    Bischloroanthrabenzoxocinone is soluble in ethanol, methanol, DMF and DMSO. 
    Mechanism of ActionBABX has been shown to inhibit agonist binding to Liver X receptors (LXR). These receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells.
    Molecular FormulaC28H24O7Cl2
    ReferencesDetermination of selectivity and efficacy of fatty acid synthesis inhibitors. Kodali S. et al. , J. Biol. Chem. 2005, 280, 1669. 

    Anthrabenzoxocinones from Streptomyces sp. as Liver X receptor ligands and antibacterial agents. Herath K. B. et al. , J. Nat. Prod. 2005, 68, 1437.