SKU: B094  / 
    CAS Number: N/A

    Burnettramic acid A aglycone

    $150.50 - $527.00

    Burnettramic acid A and its aglycone are members of a new class of antibiotics from an Australian fungus Aspergillus burnettii.  The rare bolaamphiphilic scaffold consists of β-​d-​mannose linked to a pyrrolizidinedione unit via a 26-​carbon chain. Burnettramic acid A is active against the Gram positive bacteria, B. subtilis and S. aureus, with IC50 2.3 and 5.9 µg/mL, respectively. Burnettramic acid A is a potent antifungal agent (IC50 0.5 µg/mL and 0.2 µg/mL against C. albicans and S. cerevisiae, respectively). Burnettramic acid A is also active against murine myeloma NS-1 cell line (IC50 13.8 µg/mL). Removal of the glycosyl group negates antibiotic and antifungal activity, but not activity against murine myeloma cell line (IC50 8.5 µg/mL for the aglycone).

    Molecular Formula  C35H61NO7

    Gilchrist C et al (2020)  Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov.  FG & B  143:103435

    Hang et al (2019)  Discovery and heterologous biosynthesis of the burnettramic acids: Rare PKS-​NRPS-​Derived bolaamphiphilic pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii. Org Lett 21:1287