Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.
Butyrolactone I is soluble in ethanol, methanol, DMF and DMSO.
Butyrolactone I is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Butyrolactone I inhibits the cell cycle at the G1/S and G2/M transitions. |
| References | Metabolic products of Aspergillus terreus. IX. Biosynthesis of butyrolactone derivatives isolated from strains IFO 8835 and 4100. Nitta K. et al. Chem. Pharm. Bull. 1983, 31, 1528. Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines. Suzuki M. et al. Cancer Lett. 1999, 138, 121. Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. Kitagawa M. et al. Oncogene 1993, 8, 2425. |
