Chloramphenicol Succinate Sodium is prepared from Chloramphenicol succinate using the free carboxylic acid form which ionises and readily forms in weak sodium hydroxide solutions. The sodium salt is the preferred formulation in pharma research, providing a more readily soluble product. Chloramphenicol succinate is significantly less active than Chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.
Chloramphenicol Succinate Sodium is soluble in ethanol, methanol, DMF and DMSO.
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