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Detailed Description
CAS Number: 606-59-7
Molecular Formula: C14H8N2O6
Molecular Weight: 300.2
Tariff Code: 3822.00.5090
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Specifications
Form: Solid
Appearance: White solid
Source: Semi-synthetic
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Technical Data
Solubility: Soluble in methanol or DMSO
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References
:
Fazio F et al (2012) Cinnabarinic Acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Mol. Pharmacol. 81:643
Hariamatsu R et al (2008) Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. J. Cell Biochem. 103:42
Zollner H et al (1976) Effects of cinnabarinic acid on mitochondrial respiration. Biochem. Pharmacol. 2:643
Cinnabarinic acid is an endogenous kynurenine metabolite formed from oxidative dimerization of 3-hydroxyanthranilic acid and transamination of 3-hydroxykynurenine. Cinnabarinic acid activates glutamate receptors by interacting with residues of the glutamate binding pocket of mGlu4. Cinnabarinic acid induces apoptosis in T cells through generation of reactive oxygen species, the loss of mitochondrial membrane potential and caspase activation.
CAS Number: 606-59-7
Molecular Formula: C14H8N2O6
Molecular Weight: 300.2
Tariff Code: 3822.00.5090
Form: Solid
Appearance: White solid
Source: Semi-synthetic
Solubility: Soluble in methanol or DMSO
:
Fazio F et al (2012) Cinnabarinic Acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Mol. Pharmacol. 81:643
Hariamatsu R et al (2008) Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. J. Cell Biochem. 103:42
Zollner H et al (1976) Effects of cinnabarinic acid on mitochondrial respiration. Biochem. Pharmacol. 2:643
