Novobiocic Acid is a member of the novobiocin aminocoumarin antibiotic family. Novobiocic Acid is a key intermediate in the biosynthesis of novobiocin and an important acid degradation product. While novobiocic Acid exhibits little antibacterial activity, it is more potent than novobiocin as a potentiator of etoposide BP-16 activity by inhibiting efflux from tumor cells.
Freel Meyers CL et al (2003) Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin. Biochem. 42:4179
Koinek LA and Meyer HF (1975) Novobiocic Acid synthetase. Meth. Enzymol. 43:502
Rappa G et al (2000) Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16). Oncol. Res. 12:113