SKU: F019  / 
    CAS Number: 6990-06-3

    Fusidic acid

    $64.32 - $309.96

    Fusidic acid is a bacteriostatic steroid antibiotic which targets protein synthesis in Gram-positive bacteria.

    Mechanism of ActionFusidic acid inhibits protein synthesis by preventing translocation by inhibiting ribosomal elongation factor G.
    SpectrumFusidic acid targets Gram-positive bacteria namely those which cause skin infections.
    Impurity ProfileImpurity A| ent-(24SR,17Z)-16a-(acetoxy)-3b,11b,24,25-tetrahydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholest-17(20)-en-21-oic acid (24,25-dihydroxyfusidic acid)|||| Impurity C| ent-(17Z) -3b,11b-dihydroxy-17-[(6S)-6-(1-Hydroxy-1-methylethyl)-2-oxodihydro-2H-pyran-3(4H)-ylidene]-4b,8,14-trimethyl-18-nor-5b,10a-androstan-16a-yl acetate ((24R)-24,25-dihydroxyfusidic acid 21,24-lactone)|||| Impurity D| ent-(17Z) -3b,11b-dihydroxy-17-[(6R)-6-(1-hydroxy-1-methylethyl)-2-oxodihydro-2H-pyran-3(4H)-ylidene]-4b,8,14-trimethyl-18-nor-5b,10a-androstan-16a-yl acetate ((24S)-24,25-dihydroxyfusidic acid 21,24-lactone|||| Impurity E| ent-(17Z) -16a-(acetyloxy)-3b,11b,27-trihydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholesta-17(20),24-dien-21-oic acid (27-hydroxyfusidic acid)|||| Impurity F| ent-(17Z) -16a-(acetyloxy)-3b,11b,27-trihydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholesta-17(20),24-dien-21-oic acid (27-hydroxyfusidic acid)|||| Impurity K| ent-(17Z) -3b,11b,16a-trihydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholesta-17(20),24-dien-21,16-lactone(16-deacetylfusidic acid 21,16-lactone)|||| Impurity UN1| Fusidate Sodium||||
    Microbiology ApplicationsFusidic acid is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Methicillin resistant Staphylococcus aureus (MRSA) 0.12 µg/mL - 1.0 µg/mL
    • Streptococcus epidermidis 0.25 µg/mL
    For a complete list of fusidic acid MIC values, click here.
    ReferencesCollignon, Peter, and John Turnidge. "Fusidic Acid in Vitro Activity." International Journal of Antimicrobial Agents 12.2 (1999): 45-58. Ncbi.gov. Web. 6 Dec. 2012.