Mycophenolic Acid is an antimetabolite and an active metabolite of Mycophenolate mofetil. It can inhibit DNA synthesis of T and B lymphocytes via selective inhibition of inosine monophosphate dehydrogenase. It also acts as an immunosuppressive agent commonly used solid-organ transplantation. As a selection agent, it is used for transfected animal cells expressing the E. coli gene for xanthine-guanine phosphoribosyl transferase. Mycophenolic Acid is freely soluble in methanol but insoluble in water.
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|Mechanism of Action||Mycophenolic Acid blocks inosine monophosphate dehydrogenase in the guanosine monophosphate pathway and suppresses cytokine-induced nitric oxide production.|
|Impurity Profile||Heavy Metals: ≤20ppm
Total Impurities: ≤2.0%
Individual Impurity: Not more than 0.5%
|Cell culture applications||The effect of Mycophenolic Acid on human umbilical vein endothelial cells was investigated. The compound showed multifarious effects on endothelial cells including inhibition of ICAM-1 expression, attachment of neutrophils, secretion of IL-6, and angiogenesis, which may contribute to the efficacy of Mycophenolic Acid in treatment of vasculitis.|
|Cancer Applications||Mycophenolic Acid acts as an inhibitor for inosine monophosphate dehydrogenase (IMPDH), an enzyme responsible for controlling the rate of guanine monophosphate synthesis. IMPDH is required for T-cell and B-cell growth and proliferation to a higher degree than other host cells.|
Benjanuwattra J, Chaiyawat P, Pruksakorn D, Koonrungsesomboon N (2020) Therapeutic potential and molecular mechanisms of Mycophenolic Acid as an anticancer agent. Eur J Pharmacol. PMID 32949604
de Jonge H, Naesens M, Kuypers DR (2009) New insights into the pharmacokinetics and pharmacodynamics of the calcineurin inhibitors and Mycophenolic Acid: Possible consequences for therapeutic drug monitoring in solid organ transplantation. Ther Drug Monit. 31(4):416-35. PMID 19536049
Yanfei Huang, Zhihong Liu, Haidong Huang, Hao Liu, Leishi Li (2005) Effects of Mycophenolic Acid on endothelial cells. Int. Immunopharmacol. 5(6):1029-1039