Cisplatin (cis-diammineplatinum(II) dichloride, or cis-[Pt(NH3)2Cl2, is a potent anti-tumor agent and is active against several types of solid tumors.
It is a square planer coordination complex of platinum that was discovered in 1845 by Italian chemist Michele Peyrone and was known as Peyrone's salt. The structure was elucidated in 1993 by Alfred Werner. The prefix cis means the cis isomer in which two similar ligands are adjacent. The ammine indicates an ammonia (NH3) ligand.
The 1965, researchers at Michigan State Univ. discovered that electrolysis of platinum electrodes generated a solubl platinum complex. This led to observation that this complex could regress sarcomas in rats. It ultimately It interferes with DNA replication.
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