Clavulanate Lithium (syn: Clavulanic Acid Lithium) is a stable salt preparation of Clavulanic, a natural, low-molecular weight β-lactam antibiotic. It has weak, broad-spectrum activity but offers synergistic antibacterial activity with penicillins and cephalosporins for greater efficacy against β -lactam resistant strains.
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|Mechanism of Action|
Clavulanate is a potent suicide inhibitor of β -lactamases. It forms a covalent bond with a serine residue in the enzyme’s active site. Inhibition is time-dependent and irreversible. Clavulanic acid β-lactam antibiotics bind and inhibit PBPs (penicillin binding protein) thus inhibiting bacterial cell wall synthesis.
|Microbiology Applications||Clavulanic acid had poor activity against S. aureus, Enterobacteriaceae, and P. aeruginosa. However, it can act synergistically with penicillins and cephalosporins to inhibit β -lactamase-producing S. aureus and Enterobacteriaceae.|
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