SKU: C201  / 
    CAS Number: 2030-63-9

    Clofazimine

    $38.99 - $155.96

     

    Description

    Clofazimine is a unique lipophilic rhimophenazine dye with antibacterial, antimycobacterial, anti-inflammatory, immunsupressive, and antituberculosis properties.  It was first synthesized in 1954 by a team at Trinity College, Dublin, and was launched under the trade name Lamprene in 1969 (Novartis).

    Mechanism of Action The mode of action for the biological activity of clofazimine is unknown but it is thought to act on neutrophils and monocytes.
    Spectrum Clofazimine is active against Gram-positive bacteria including multiple drug resistant (MDR) bacteria, with little to no activity against Gram-negative bacteria.  It is also active against Mycobacteria.
    Molecular Formula C27H22Cl2N4
    References

    Arbiser JL and Moschella SM (1995 Clofazimine: A Review of its medical uses and mechanisms of action." J. Am. Acad. Dermatol 32(2): 241-47  PMID 7829710

    Van Rensburg CE, Jooné GK, O'Sullivan JF, Anderson R (1992)  Antimicrobial activities of clofazimine and B669 are mediated by lysophospholipids. Antimicrob. Agents Chemother. 3612): 2729-2735  PMID  1482140