Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A.
Concanamycin B is soluble in ethanol, methanol, DMF and DMSO.
Concanamycin B is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Concanamycin B inhibits vacuolar H(+)-ATPase and the expression of newly-synthesized MHC class II molecules and suppresses bone resorption in vitro. |
| References | Structures of concanamycins B and C. Kinashi H. et al. J. Antibiot. 1982, 35, 1618. Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro. Woo J.T. et al. Biol. Pharm. Bull. 1996, 19, 297. Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. Ito K. et al. J. Antibiot. 1995, 48, 488. |
