SKU: C183  / 
    CAS Number: 81552-33-2

    Concanamycin B

    $266.16 - $931.59
    Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A.

    Concanamycin B is soluble in ethanol, methanol, DMF and DMSO.
    Mechanism of ActionConcanamycin B inhibits vacuolar H(+)-ATPase and the expression of newly-synthesized MHC class II molecules and suppresses bone resorption in vitro.
    ReferencesStructures of concanamycins B and C. Kinashi H. et al. J. Antibiot. 1982, 35, 1618.

    Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro. Woo J.T. et al. Biol. Pharm. Bull. 1996, 19, 297.

    Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. Ito K. et al. J. Antibiot. 1995, 48, 488.