Cyclo(Δ-Ala-L-Val) is a diketopiperazine formed by the fusion of Δ-alanine and valine, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, cyclo(Δ-Ala-L-Val) is capable of activating N-acylhomoserine lactones (AHLs). Cyclo(Δ-Ala-L-Val) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems.
Cyclo(Δ-Ala-L-Val) is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
Cyclo(Δ-Ala-L-Val) is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
| Mechanism of Action | While the mode of action of cyclo(Δ-Ala-L-Val) is not known, its activity suggests the existence of cross talk among bacterial signalling systems. |
| Molecular Formula | C8H12N2O2 |
| References | Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram-negative bacteria. Holden M.T.G. et al. Mol. Microbiol. 1999, 33, 1254. |
