SKU: C191  / 
    CAS Number: 19553-26-5

    Cyclopenin

    $207.25 - $725.37
    Cyclopenin is one of an unusual family of benzodiazepine metabolites produced by a number of Penicillium species. Often mistakenly referred to as a mycotoxin, cyclopenin shows little toxicity against mammalian cells, bacteria or fungi in vitro. Cyclopenin is an intermediate in the biosynthesis of 3-O-methyl viridicatin, a strong inhibitor of TNF?-induced replication HIV. Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite.

    Cyclopenin is soluble in ethanol, methanol, DMF or DMSO. 
    Molecular FormulaC17H14N2O3
    ReferencesStudies in the biochemistry of microorganisms. 93. Cyclopenin, a nitrogen-containing metabolic product of Penicillium cyclopium Westling. Bracken A. et al. Biochem J. 1954, 57, 587. 

    Isolation and characterization of the fungal metabolite 3-O-methylviridicatin as an inhibitor of tumor necrosis factor alpha-induced human immunodeficiency virus replication. Heguy A. et al. Antivir. Chem. Chemother. 1998, 9, 149.