SKU: C041  / 
    CAS Number: 68-41-7

    D-Cycloserine

    $60.24 - $223.41

    D-Cycloserine is an amino acid analog antibiotic. D-cycloserine acts as a competitive inhibitor of D-alanine, an essential amino acid during peptidoglycan synthesis.  It is a broad-spectrum antibiotic that can be used as a selective agent in several types of isolation media.  D-cycloserine is soluble in aqueous solution.

    Mechanism of ActionD-Cycloserine inhibits cell wall biosynthesis, specifically the D-Ala peptide bond formation. It competitively inhibits alanine racemase (which produces D-alanine) and D-alanine ligase, which joins the terminal 2 amino acid residues together. D-cycloserine is a ligand for the N-methyl-D-aspartate (NMDA) glycine receptor and has partial agonist characteristics, and has proven to have pharmacological activity in enhancing extinction memory.
    SpectrumD-Cycloserine is a broad-spectrum antibiotic that can be used against the causal agent of tuberculosis (Mycobacterium tuberculosis).
    Microbiology ApplicationsD-Cycloserine can be used as a selective agent in several types of isolation media:

    Perfringens Agar - SFP and TSC selective supplements

    Clostridium difficile agar - Isolation of Clostridium difficile

    m-CP Medium - Membrane C. perfringens Selective Supplement

    Molecular FormulaC3H6N2O2
    References

    Hood WF,  Compton RP,  and Monahan JB (1989)  D-Cycloserine: A ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics. Neurosci Lett 98(1):91-95  PMID 2540460

    Lambert MP and Neuhaus FC (1972)  Mechanism of D-Cycloserine action: Alanine racemase from Escherichia coli. J. Bacteriol.  110(3):978-987  PMID 4555420

    Peters J and De Vries TJ (2013)  D-Cycloserine administered directly to infralimbic medial prefrontal cortex enhances extinction memory in sucrose-seeking animals. Neurosci.  230:24-30  PMID  23159319

    MICMycobacterium smegmatis| 2.56 - 300 || Staphylococcus aureus| 16 - 32 ||