Dalbavancin is a semi-synthetic glycopeptide prepared from A40926 by introducing a positively charged lipophilic moiety in a previously unexplored region of the natural glycopeptide. This modification provides a longer in vivo half life, and improved in vitro activity against a variety of Gram positive and multi-drug resistant isolates such as MRSA and MRSE.
Dalbavancin is soluble in ethanol, methanol, DMF and DMSO.
Dalbavancin is soluble in ethanol, methanol, DMF and DMSO.
Molecular Formula | C88H100Cl2N10O28 |
References | New semisynthetic glycopeptides, MDL63,246 and MDL63,042, and other amide derivatives of Antibiotic A-40,926 active against highly glycopeptide-resistant VanA Enterococci. Malabarba A.J. Antibiot. 1995, 48, 869. Dalbavancin: a novel antimicrobial. Chen A.Y. et al. Int. J. Clin. Pract. 2007, 61, 853. |