SKU: D032  / 
    CAS Number: 64-73-3

    Demeclocycline hydrochloride

    $53.19 - $469.46
    Demeclocycline hydrochloride is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity.

    Demeclocycline hydrochloride is soluble in ethanol, methanol, DMF, DMSO, and water.
    Mechanism of ActionDemeclocycline HCl blocks protein synthesis by binding to the 30S and 50S ribosomal subunits.
    Molecular FormulaC21H22Cl2N2O8
    ReferencesA new family of antibiotics: the demethyltetracyclines. McCormack J.R.D. et al. J. Am. Chem. Soc. 1957, 79, 4561.

    Structure-activity relationships in the tetracycline series. Blackwood R.K. & English A.R. In Structure-activity relationships among the semisynthetic antibiotics. (Ed. Perlman D. Academic Press, London) 1977, 397.