Clindamycin Hydrochloride is a broad-spectrum antibiotic and antiparasitic agent. It is a semi-synthetic derivative of Lincomycin, a natural lincosamide isolated from Streptomyces lincolnensis in 1966. Clindamycin Hydrochloride is freely soluble in water.
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|Mechanism of Action||Lincosamides inhibit bacterial protein synthesis by binding the 50S ribosomal subunit and interfering with tRNA activity during translation.|
|Spectrum||Clindamycin is a broad-spectrum antibiotic targeting primarily Gram-positive and Gram-negative bacteria such as Clostridium and Bacteroides species.|
|Microbiology Applications||Clindamycin is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative anaerobes. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative ranges include: |
For a complete list of Clindamycin MIC values, click here.
|Eukaryotic Cell Culture Applications|
HIV-infected cells (MOLT3 cells) were incubate with clindamycin in increasing concentrations, and did not result in increased cell death compared to uninfected control cells. (Wijsman et al, 2013).
The effects of clindamycin and its metabolites on mammalian cell lines (mouse leukemia L1210, human oral carcinoma KB, human acute myelogenous leukemia RPMI 6410, and human lymphocyte RPMI 1788) were evaluated. Metabolites clindamycin sulfoxide and clindamycose were nontoxic, wherease N-demethyl clindamycin showed cytotoxic effects in culture (Li et al, 1977).
|Molecular Formula||C18H33ClN2O5S · HCl|
|Potency (on a dry basis)||≥800 µg/mg (C18H33ClN2O5S)|
Dhawan VK and Thadepalli H. (1982) Clindamycin: A review of fifteen years of experience. Clin. Infect. Dis. 4(6):1133-1153 PMID 6818656
Li LH, Kuentzel K L, Shugars KD and Bhuyan BK (1977) Cytotoxicity of several marketed antibiotics on mammalian cells in culture. J. Antibiot (Tokyo) 30(6):506-512 PMID 560364
Lovmar, M and Tanel T (2003) The Mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J. Molec. Microbiol. 330(5 ): 1005-014 PMID 12860123
Magerlein BJ et al (1966) Chemical modification of lincomycin. Antimicrob Agents Chemother. 6:727 PMID 5985307
Wijsman JA, Dekaban GA and Rieder MJ (2013) Differential toxicity of reactive metabolites of clindamycin and sulfonamides in HIV-infected cells: Influence of HIV infection on clindamycin toxicity in vitro. J. Clin. Pharmacol. 45(3):346-351 PMID 15703369
|MIC||Diplococcus pneumoniae| 0.005 - 0.02 || Haemophilus influenzae| 3.1 - 25 |||