SKU: D046  / 
    CAS Number: 187865-22-1

    Derquantel

    $266.16 - $931.59
    Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. Derquantel is a potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. Derquantel, like other paraherquamides, induces a flaccid paralysis in nematodes thought to be due to inhibition of nicotinic acetylcholine receptors acting as an antagonist of acetylcholine.

    Derquantel is soluble in ethanol, methanol, DMF and DMSO. 
    Molecular FormulaC28H37N3O4
    ReferencesLigands of the nicotinic acetylcholine receptor as insecticides. Nauen R. et al. Pestic. Sci. 1999, 55, 608-610.

    Semisynthesis of 2-deoxo- and 3-epi-paraherquamide A. Lee B.H. et al. Bioorg. Med. Chem. Lett. 2001, 11, 553-554.

    Marcfortine and paraherquamide class of anthelmintics: Discovery of PNU-141962. Lee B.H. et al. Current Topics in Med. Chem. 2002, 2, 779.