Descarbamylnovobiocin is a member of the novobiocin aminocoumarin antibiotic family found as a minor co-metabolite of
novobiocin fermentation and produced as an alkaline degradation product. Like novobiocin, Descarbamylnovobiocin is an
inhibitor of the bacterial type II topoisomerase, DNA gyrase. It is less effective than novobiocin in eliminating the wild-type plasmid pMG110 from E. coli.
| Molecular Formula | C30H35NO10 |
| References | Flatman RH et al (2006) Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis. Antimicrob. Agents Chemother. 50: 1136 Hooper DC et al (1984) Elimination of plasmid pMG110 from Escherichia coli by novobiocin and other inhibitors of DNA gyrase. Antimicrob. Agents Chemother. 25:586 Wolf FJ et al (1960) Decarbamoylnovobiocins. US Patent 2938899 |