SKU: D100  / 
    CAS Number: 75057-97-5


    $200.32 - $701.10

    Descarbamylnovobiocin is a member of the novobiocin aminocoumarin antibiotic family found as a minor co-metabolite of
    novobiocin fermentation and produced as an alkaline degradation product. Like novobiocin, Descarbamylnovobiocin is an
    inhibitor of the bacterial type II topoisomerase, DNA gyrase. It is less effective than novobiocin in eliminating the wild-type plasmid pMG110 from E. coli.

    Molecular Formula  C30H35NO10 

    Flatman RH et al (2006)  Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis. Antimicrob. Agents Chemother. 50: 1136

    Hooper DC et al (1984)  Elimination of plasmid pMG110 from Escherichia coli by novobiocin and other inhibitors of DNA gyrase. Antimicrob. Agents Chemother. 25:586

    Wolf FJ et al (1960)  Decarbamoylnovobiocins. US Patent 2938899