Enramycin is a polypeptide antibiotic produced by Streptomyces fungicidus and has a role as a food additive in Japan. Enramycin is composed of two different compounds: Enramycin A and Enramycin B. The ratio of A and B varies but is typically ~70:30. Enramycin is slightly soluble in water and freely soluble in DMF and dilute HCl solution.
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|Mechanism of Action
|Enramycin acts as a MurG inhibitor involved in peptidoglycan synthesis in Gram-positive bacteria. MurG catalyzes the transglycosylation reaction in the final step of peptidoglycan biosynthesis. Inhibition of this step greatly compromises cell wall integrity leading to cell lysis.
|Enramycin has strong antibacterial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and inhibits the development of major gut flora pathogens. Resistance or cross-resistance with existing antibiotics has rarely been observed.
|Enramycin A: C107H138Cl2N26O31
Enramycin B: C108H140Cl2N26O31
|Acids (Dilute HCl): Freely soluble
Dimethylformamide: Freely soluble
Water: Slightly soluble
|Enramycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive microbial isolates. Medical microbiologists use this information to recommend antibiotic treatment options.
|Fang X et al (2006) The mechanism of action of Ramoplanin and enduracidin. Royal Soc. Chem. 2: 69-76 PMID 16880924
|Clostridium perfringins| 0.05 － 1.6|| Staphylococcus aureus| 0.013 － 0.413||