Erythromycin C (3''-O-demethylerythromycin) is a minor co-metabolite of Erythromycin. Other metabolites include A, B, and D Erythromycin C exhibits a narrower spectrum of antibiotic activity and is less active than A and B. Erythromycin C is soluble in ethanol, methanol, DMF and DMSO but has limited water solubility.
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| Application | Researchers were successful in reconstituting the erythromycin biosynthetic pathway in E. coli to produce Erythromycin C and D involving combining 2 tailoring genes and 14 genes involved in deoxysugar biosynthesis and attaching the megalomicin gene cluster (Peirú et al., 2005). |
| References | Tsuii K and Goetz JF (1978) HPLC as a rapid means of monitoring erythromycin and tetracycline fermentation processes. J. Antibiot. 31:302 PMID 659328 Kibwage O et al (1985) Antibacterial activities of erythromycins A, B, C, and D and some of their derivatives. Antimicrob. Agents Chemother. 28:630 PMID 4091529 Peiru S et al (2005) Production of the potent antibacterial polyketide erythromycin C in Escherichia coli. Appl. Environ. Microbiol 71(5):2539-2547 PMID 15870344 |
