SKU: E055  / 
    CAS Number: 111321-02-9

    Erythromycin A oxime

    $93.40 - $326.86
    Erythromycin A 9-oxime is a semi-synthetic analog Erythromycin prepared as means of overcoming acid lability and improving oral absorption of Erythromycin A while retaining antibacterial potency. Although not developed as a commercial product, Erythromycin Oxime was pivotal in the development of the ring expanded aza-erythromycins (e.g. azithromycin) and the oxime ethers (e.g. roxithromycin).

    Erythromycin A 9-oxime is soluble in water, ethanol, methanol, DMF and DMSO.

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    ReferencesGasc JC et al (1994) New ether oxime derivative of erythromycin A structure-activity relationship study. J. Antibiot. 44: 313

    Djokic SJ (1986) Erythromycin series. Part 11. Ring expansion of erythromycin A oxime by the Beckmann rearrangement. Chem. Soc. Perkin Trans.: 1881