SKU: E003  / 
    CAS Number: 3521-62-8

    Erythromycin Estolate

    $111.11

    Erythromycin estolate, a derivative of Erythromycin, is the lauryl sulfate salt of the proprionic ester of Erythromycin.  It acts as a bacteriostatic agent, and has a role as an enzyme inhibitor.  Erythromycin estolate is freely soluble in organic solvents but practically insoluble in water.

    For other Erythromycin products, click here.

    Mechanism of ActionMacrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to Erythromycin is commonly attributed to mutations in 50S rRNA preventing erythromycin binding allowing the cell to synthesize proteins free of error.
    SpectrumErythromycin is a broad-spectrum antibiotic commonly targeting targeting Gram-negative and Gram-positive bacteria. It is also effective against Mycoplasmas including Mycoplasma pneumoniae.
    Microbiology ApplicationsErythromycin Estolate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive, Gram-negative, and Mycoplasmas species.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:
    • Mycoplasma pneumoniae 0.0019 µg/mL – 0.0078 µg/mL
    • Legionella pneumophila 0.008 µg/mL – 1 µg/mL
    • For a  complete list of Erythromycin MIC values, click here.
    Eukaryotic Cell Culture ApplicationsCytotoxicity of of erythromycin estolate was compared to other macrolides in cultured human non-malignant Chang liver cells and was found the most toxic when compared to Erythromycin, erythromycin-11,12-cyclic carbonate, roxithromycin, clarithromycin and azithromyciin (Viluksel et al, 1996).

    Gene expression microarrays can prioritize lead compounds in drug development research.  In vitro primary rat hepatocytes were exposed to 11 known hepatotoxicants in low-density DNA microarrays with 59 genes known as toxic and metabolic markers for transcription profiling.  Erythromycin estolate was found to cluster in the group with drugs that induced cholestatis.  Gene expression data correlated well with the literature (de Longueville et al, 2003).
    Molecular FormulaC40H71NO14 · C12H26SO4
    SolubilityFreely soluble in organic solvents (ethanol, acetone, chloroform, polyethylene glycol, and benzene). It is insoluble in water.
    Referencesde Longueville, F et al (2003) Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes. Toxicolog. Sci. 75(2):378-392 PMID 12883083

    Lovmar, M and Tenson T (2003) The Mechanism of action of macrolides, Lincosamides and Streptogramin B reveals the nascent peptide exit path in the ribosome. J. Molec. Microbiol. 330(5):1005-1014 PMID 12860123

    Potthast H, Schug B, Elze M, Schwerdtle R, Blume H (1995) Comparison of the bioavailabilities of erythromycin estolate and erythromycin ethylsuccinate dry suspension preparations in steady state. Pharmazie 50(1):56-60 PMID 7886126

    Viluksel M, Vainio PJ, Raimo K, Tuominen RK (1996) Cytotoxicity of macrolide antibiotics in a cultured human liver cell line, J. Antimicrob. Chemother. 38 (3):465–473 PMID 8889721
    MICAggregatibacter actinomycetemcomitans| 8 - >32| 821| Alcaligenes faecalis (ATCC 1004)| 20 - ?| 1019| Bacillus cereus| 18 - ?| 914| Bacillus cereus| 18 - ?| 884| Bacillus cereus (ATCC 10702)| 0.0977 - ?| 1536| Bacillus cereus (ATCC 10702)| 1 - ?| 1302| Bacillus cereus (ATCC 14579)| 8 - ?| 891| Bacillus cereus (RSKK 867)| 10.7 - ?| 841| Bacillus circulans (pH 7.0)| ≤0.03 - 16| 818| Bacillus circulans (pH 8.0)| ≤0.03 - 8| 818| Bacillus pumilus (ATCC 14884)| 2 - ?| 1302| Bacillus pumilus (ATCC 14884)| 2 - ?| 1183| Bacillus pumilus (ATCC 14884)| 12.5 - ?| 1536| Bacillus spp.| ≤0.12 - >16| 18| Bacillus spp.| ≤0.5 - 4| 462| Bacillus subtilis| 0.12 - ?| 288| Bacillus subtilis| 0.5 - ?| 794| Bacillus subtilis| 412 - ?| 1183| Bacillus subtilis| 412 - ?| 1183| Bacillus subtilis (ATCC 585969)| <0.125 - ?| 409| Bacillus subtilis (ATCC 6633)| 0.125 - ?| 1019| Bacteroides capillosus (pH 7.0)| ≤0.03 - 2| 818| Bacteroides capillosus (pH 8.0)| ≤0.03 - 1| 818| Bacteroides fragilis| 0.25 - 128| 948| Bacteroides fragilis| 0.25 - 128| 401| Bacteroides fragilis (ATCC 25285)| >8 - ?| 650| Bacteroides fragilis (NCTC 9343)| 1 - ?| 401| Bacteroides tectum| 0.25 - 1| 1460| Bacteroides ureolyticus| 0.125 - 2| 1460| Bacteroides ureolyticus (pH 7.0)| ≤0.03 - 2| 818| Bacteroides ureolyticus (pH 8.0)| ≤0.03 - 1| 818| Bifidobacterium adolescentis (ATCC 15704)| 3.95 - ?| 741| Bifidobacterium animalis (ATCC 27536)| >1.95 - <3.95| 741| Bifidobacterium bifidum (ATCC 15696)| 7.8 - ?| 741| Bifidobacterium bifidum (Bb12)| 15.62 - ?| 741| Bifidobacterium breve (ATCC 15700)| 1.95 - ?| 741| Bifidobacterium breve (pH 7.0)| ≤0.03 - 16| 818| Bifidobacterium breve (pH 8.0)| ≤0.03 - 8| 818| Bifidobacterium Infantis (ATCC 15697)| 15.6 - ?| 741| Bifidobacterium longum (ATCC 15707)| <0.98 - ?| 741| Bifidobacterium longum (ATCC 15708)| >1.95 - <3.95| 741| Bifidobacterium longum (pH 7.0)| ≤0.03 - 16| 818| Bifidobacterium longum (pH 8.0)| ≤0.03 - 8| 818| Bifidobacterium longum (RBL9)| <0.98 - ?| 741| Bifidobacterium pseudolongum (ATCC 25526)| 3.9 - ?| 741| Bifidobacterium sp. (RBL67)| 1.95 - ?| 741| Bifidobacterium sp. (RBL68)| 3.9 - ?| 741| Bifidobacterium sp. (RBL69)| <0.98 - ?| 741| Bifidobacterium sp. (RBL70)| <0.98 - ?| 741| Bifidobacterium sp. (RBL75)| 0.98 - ?| 741| Bifidobacterium sp. (RBL76)| 1.95 - ?| 741| Bifidobacterium thermophilum (ATCC 25866)| 0.98 - 1.95| 741| Bilophila wadsworthia| 4 - 32| 1460| Borrelia afzelii (EB1)| ≤0.015 - ?| 402| Borrelia afzelii (EB1)| 0.0625 - ?| 261| Borrelia afzelii (EB2)| 0.0156 - ?| 261| Borrelia afzelii (FAC-1)| 0.0312 - ?| 261| Borrelia afzelii (FEM1)| ≤0.015 - ?| 402| Borrelia afzelii (FEM1)| 0.0156 - ?| 261| Borrelia afzelii (PKo)| 0.03 - ?| 402| Borrelia afzelii (Vs461)| 0.0078 - ?| 261| Borrelia bissettii (25015)| 0.0312 - ?| 261| Borrelia bissettii (25015)| 0.06 - ?| 402| Borrelia burgdorferi| ≤0.015 - 0.125| 402| Borrelia burgdorferi| 0.004 - 0.008| 15| Borrelia burgdorferi (297)| 0.0039 - ?| 261| Borrelia burgdorferi (ATCC 35210 + B31)| 0.0156 - ?| 261| Borrelia burgdorferi (LW2)| 0.0312 - ?| 261| Borrelia burgdorferi (PKa-I)| 0.0156 - ?| 261| Borrelia burgdorferi (Sensu stricto + B31)| 0.06 - ?| 402| Borrelia burgdorferi (Sensu stricto + LW2)| 0.06 - ?| 402| Borrelia burgdorferi (Sensu stricto + PKa-I)| ≤0.015 - ?| 402| Borrelia burgdorferi (Z25)| 0.0078 - ?| 261| Borrelia burgdorferi S.L.| <0.007 - 1| 1129| Borrelia garinii (A87SB)| 0.0078 - ?| 261| Borrelia garinii (G1)| ≤0.015 - ?| 402| Borrelia garinii (JP2)| 0.0156 - ?| 261| Borrelia garinii (PSth)| ≤0.015 - ?| 402| Borrelia garinii (PSth)| 0.0625 - ?| 261| Borrelia garinii (PTrob)| 0.0078 - ?| 261| Borrelia garinii (PTrob)| ≤0.015 - ?| 402| Borrelia garinii (ZQ1)| 0.0156 - ?| 261| Borrelia valaisiana (VS116)| 0.0156 - ?| 261| Borrelia valaisiana (VS116)| 0.03 - ?| 402| Brachyspira hyodysenteriae (2000-2004 + Spain)| 16 - >256| 603| Brachyspira hyodysenteriae (2006-2007 + Spain)| >256 - ?| 603| Brachyspira hyodysenteriae (ATCC 27164)| 4 - 32| 603| Brachyspira hyodysenteriae (ATCC 27164)| 4 - ?| 603| Brachyspira hyodysenteriae (ATCC 27164)| 8 - ?| 603| Brachyspira hyodysenteriae (ATCC 31212)| >256 - ?| 603| Brachyspira hyodysenteriae (ATCC 31212)| >256 - ?| 603| Branhamella catarrhalis| ≤0.08 - 0.6| 248| Brevibacterium casei| 0.5 - 4| 965| Brevibacterium spp.| ≤0.03 - >64| 185| Brevibacterium spp.| ≤0.015 - >128| 488| Brucella| 0.5 - 8| 1388| Brucella melitensis (pH 5.0)| 32 - >256| 318| Brucella melitensis (pH 7.0)| 0.5 - 256| 318| Brucella suis (ATCC 27531)| 0.98 - 1.95| 741| Burkholderia cepacia| >128 - ?| 733| Burkholderia cepacia (small colony variants)| 128 - ?| 733| Campylobacter coli| 0.125 - 128| 277| Campylobacter coli| 1 - >32| 833| Campylobacter coli| 0.5 - >1024| 822| Campylobacter coli (Finland)| 0.5 - 8| 822| Campylobacter coli (Iran Shiraz)| 8 - 32| 1393| Campylobacter coli (Iran Tonekabon)| 8 - 32| 1393| Campylobacter concisus (pH 7.0)| 0.25 - 2| 818| Campylobacter concisus (pH 8.0)| 0.125 - 1| 818| Campylobacter fetus| ≤0.06 - 4| 825| Campylobacter gracilis (pH 7.0)| 0.25 - 2| 818| Campylobacter gracilis (pH 8.0)| 0.125 - 1| 818| Campylobacter jejuni| 0.25 - >32| 833| Campylobacter jejuni| 0.125 - 128| 277| Campylobacter jejuni| 0.5 - >1024| 822| Campylobacter jejuni (ATCC 33291)| 13.9 - ?| 841| Campylobacter jejuni (Finland)| 0.5 - 8| 822| Campylobacter jejuni (Iran Shiraz)| 8 - 32| 1393| Campylobacter jejuni (Iran Tonekabon)| 8 - 64| 1393| Campylobacter lari (Iran Shiraz)| 8 - 32| 1393| Campylobacter lari (Iran Tonekabon)| 8 - 32| 1393| Campylobacter mucosalis (pH 7.0)| 0.25 - 2| 818| Campylobacter mucosalis (pH 8.0)| 0.125 - 1| 818| Campylobacter rectus (pH 7.0)| 0.25 - 2| 818| Campylobacter rectus (pH 8.0)| 0.125 - 1| 818| Campylobacter showae (pH 7.0)| 0.25 - 2| 818| Campylobacter showae (pH 8.0)| 0.125 - 1| 818| Campylobacter spp.| ≤0.12 - 2| 829| Campylobacter sputorum (pH 7.0)| 0.25 - 2| 818| Campylobacter sputorum (pH 8.0)| 0.125 - 1| 818| Capnocytophaga ochracea (pH 7.0)| ≤0.03 - 2| 818| Capnocytophaga ochracea (pH 8.0)| ≤0.03 - 1| 818| Capnocytophaga spp.| 2 - ?| 821| Cellulomonas biazotea| 4 - ?| 827| Cellulomonas cellasea| ≤0.03 - ?| 827| Cellulomonas fermentans| 0.06 - ?| 827| Cellulomonas fimi| 4 - ?| 827| Cellulomonas flavigena| 0.25 - ?| 827| Cellulomonas flavigena| 0.25 - ?| 827| Cellulomonas gelida| 0.5 - ?| 827| Cellulomonas hominis (CDC A-3 + CE39)| 2 - ?| 827| Cellulomonas hominis (CDC A-3 + CE40)| 1 - ?| 827| Cellulomonas uda| 0.5 - ?| 827| Chlamydia pneumonia| 0.015 - 0.06| 8| Chlamydia pneumonia| 0.015 - 0.25| 948| Chlamydia pneumonia| 0.008 - 0.06| 141| Chlamydia pneumonia| 0.015 - 0.25| 495| Chlamydia pneumonia| 0.015 - 0.5| 5| Chlamydia pneumonia (AR-39)| 0.06 - ?| 409| Chlamydia pneumonia (CV-1)| 0.1 - ?| 292| Chlamydia pneumonia (CV-3)| 0.05 - ?| 292| Chlamydia pneumonia (CV-4)| 0.1 - ?| 292| Chlamydia pneumonia (CV-4)| 0.1 - ?| 292| Chlamydia pneumonia (CV-5)| 0.1 - ?| 292| Chlamydia pneumonia (CV-6)| 0.1 - ?| 292| Chlamydia pneumonia (CWL)| 0.05 - ?| 292| Chlamydia pneumonia (MUL-1)| 0.05 - ?| 292| Chlamydia pneumonia (TW-183)| 0.25 - ?| 963| Chlamydia psittaci (Budgerigar)| 0.25 - ?| 963| Chlamydia psittaci (Izawa)| 0.25 - ?| 963| Chlamydia psittaci (MP)| 0.25 - ?| 963| Chlamydophila pneumonia| 0.015 - 0.25| 954| Chlamydophila pneumonia| 0.015 - 0.25| 1113| Citrobacter freundii (TP)| >16 - ?| 220| Clostridium clostridioforme| 0.25 - >32| 1460| Clostridium difficile| 0.25 - 256| 948| Clostridium difficile| 0.25 - >32| 1460| Clostridium difficile| 0.125 - 256| 764| Clostridium innocuum| 0.5 - >32| 1460| Clostridium perfringens (ATCC 13124)| 2 - ?| 650| Clostridium ramosum| 0.5 - >32| 1460| Clostridium spiroforme (A7)| >8 - ?| 650| Clostridium spiroforme (A8)| >8 - ?| 650| Clostridium spiroforme (B61)| >8 - ?| 650| Clostridium spiroforme (BA 1)| 1 - ?| 650| Clostridium spiroforme (C121)| >8 - ?| 650| Clostridium spiroforme (CED 1)| >8 - ?| 650| Clostridium spiroforme (D11)| >8 - ?| 650| Clostridium spiroforme (D13)| >8 - ?| 650| Clostridium spiroforme (D14)| >8 - ?| 650| Clostridium spiroforme (NCTC 11493)| >8 - ?| 650| Clostridium spiroforme (RPO 980)| 1 - ?| 650| Collinsella aerofaciens (pH 7.0)| ≤0.03 - 0.25| 818| Collinsella aerofaciens (pH 8.0)| ≤0.03 - 0.125| 818| Corynebacterium (CDC group G)| ≤0.06 - >=64| 965| Corynebacterium afermentans| ≤0.015 - >128| 488| Corynebacterium amycolatum| 0.125 - >64| 185| Corynebacterium amycolatum| 0.5 - >128| 488| Corynebacterium amycolatum| ≤0.06 - >=64| 965| Corynebacterium aquaticum| ≤0.12 - >16| 18| Corynebacterium argentoratense| ≤0.06 - >=64| 965| Corynebacterium auris| ≤0.06 - >=64| 965| Corynebacterium coyleae| ≤0.06 - >=64| 965| Corynebacterium diphtheriae| ≤0.06 - ?| 965| Corynebacterium glucuronolyticum| ≤0.06 - >=64| 965| Corynebacterium jeikeium| >4 - ?| 462| Corynebacterium jeikeium| ≤0.12 - >16| 18| Corynebacterium jeikeium| 0.06 - >64| 185| Corynebacterium jeikeium| ≤0.06 - >=64| 965| Corynebacterium jeikeium| ≤0.015 - >128| 488| Corynebacterium macginleyi| ≤0.06 - ?| 965| Corynebacterium minutissimum| ≤0.06 - >=64| 965| Corynebacterium minutissimum| ≤0.015 - 16| 488| Corynebacterium minutissimum| ≤0.03 - >64| 185| Corynebacterium minutissimum| ≤0.12 - >16| 18| Corynebacterium mucifaciens| ≤0.06 - >=64| 965| Corynebacterium pseudodiphtheriticum| ≤0.015 - 16| 488| Corynebacterium pseudodiphtheriticum| ≤0.06 - >=64| 965| Corynebacterium spp.| 1 - >8| 123| Corynebacterium spp.| 0.004 - >128| 15| Corynebacterium spp. (group 2)| ≤0.12 - >16| 18| Corynebacterium spp. (group ANF-1)| ≤0.12 - >16| 18| Corynebacterium spp. (group ANF-3)| ≤0.12 - >16| 18| Corynebacterium striatum| ≤0.06 - >=64| 965| Corynebacterium striatum| 2 - >64| 185| Corynebacterium striatum| ≤0.12 - >16| 18| Corynebacterium striatum| ≤0.015 - >128| 488| Corynebacterium ulcerans| ≤0.06 - ?| 965| Corynebacterium ulcerans| ≤0.06 - ?| 965| Corynebacterium urealyticum| ≤0.015 - >128| 488| Corynebacterium urealyticum| ≤0.06 - >=64| 965| Corynebacterium urealyticum| ≤0.12 - >16| 18| Corynebacterium urealyticum| ≤0.12 - >16| 18| Corynebacterium urealyticum| 0.125 - >64| 185| Coryneform (CDC group I3)| ≤0.015 - >128| 488| Dermabacter hominis| ≤0.06 - >=64| 965| Dialister pneumosintes (pH 7.0)| ≤0.03 - 2| 818| Dialister pneumosintes (pH 8.0)| ≤0.03 - 1| 818| Diphtheroids (JK group)| 0.5 - >512| 448| Diplococcus pneumoniae| 0.002 - 0.02| 1413| Edwardsiella hoshinae| 8 - 32| 1409| Edwardsiella ictaluri| 4 - 64| 1409| Edwardsiella tarda| 8 - 64| 1409| Eikenella corrodens| ≤0.25 - 8| 144| Eikenella corrodens| >32 - ?| 821| Enterobacter aerogenes (41)| >16 - ?| 220| Enterobacter aerogenes (TP)| >16 - ?| 220| Enterobacter cloacae (Vero)| >16 - ?| 220| Enterococci| 0.25 - 128| 401| Enterococci (ampicillin-resistant + vancomycin-resistant)| 2 - ?| 733| Enterococci (ampicillin-susceptible + vancomycin-resistant)| 128 - ?| 733| Enterococcus| ≤0.125 - 8| 1036| Enterococcus avium| ≤0.12 - >4| 1130| Enterococcus avium| ≤0.5 - >4| 462| Enterococcus avium| ≤0.12 - >64| 371| Enterococcus avium| ≤0.12 - >16| 18| Enterococcus casseliflavus| ≤0.12 - >4| 1130| Enterococcus casseliflavus| ≤0.12 - >16| 18| Enterococcus casseliflavus (van(C))| ≤0.5 - >4| 462| Enterococcus cecorum| ≤0.12 - >16| 18| Enterococcus durans| ≤0.12 - >4| 1130| Enterococcus durans| ≤0.5 - >4| 462| Enterococcus durans| ≤0.12 - >16| 18| Enterococcus durans (D78 + vancomycin-resistant)| >16 - ?| 220| Enterococcus faecalis| 0.5 - >128| 89| Enterococcus faecalis| 0.5 - >32| 16| Enterococcus faecalis| 0.25 - >4| 1130| Enterococcus faecalis| 1 - >4| 462| Enterococcus faecalis| ≤0.12 - >16| 18| Enterococcus faecalis| 0.25 - >8| 123| Enterococcus faecalis| ≤0.12 - >64| 371| Enterococcus faecalis| 0.125 - >128| 178| Enterococcus faecalis| 0.1 - >100| 1030| Enterococcus faecalis| 2 - ?| 733| Enterococcus faecalis| 16 - ?| 1132| Enterococcus faecalis| 92 - ?| 884| Enterococcus faecalis (ATCC 29212)| 1 - ?| 397| Enterococcus faecalis (ATCC 29212)| 2 - ?| 409| Enterococcus faecalis (ATCC 29212)| 4 - ?| 401| Enterococcus faecalis (ATCC 29212)| >16 - ?| 220| Enterococcus faecalis (ATCC 29212)| 256 - ?| 891| Enterococcus faecalis (broiler isolate)| 0.2 - >100| 1030| Enterococcus faecalis (erythromycin-resistant + vancomycin-susceptible)| 1 - >512| 448| Enterococcus faecalis (erythromycin-susceptible + vancomycin-susceptible)| 0.06 - 0.5| 448| Enterococcus faecalis (erythromycin-susceptible)| 0.5 - ?| 289| Enterococcus faecalis (KZN)| 12.5 - ?| 1536| Enterococcus faecalis (MicroScan automated panel)| ≤0.5 - >=8| 1038| Enterococcus faecalis (NCTC 775T)| 0.5 - ?| 220| Enterococcus faecalis (Periapical lesions)| 0.38 - >256| 407| Enterococcus faecalis (pig isolate)| 0.1 - >100| 1030| Enterococcus faecalis (V583)| 2 - ?| 220| Enterococcus faecalis (vancomycin-resistant)| 0.5 - >4| 1130| Enterococcus faecalis (vancomycin-resistant)| 4 - >4| 462| Enterococcus faecalis (vancomycin-resistant)| 2 - >8| 175| Enterococcus faecalis (vancomycin-resistant)| 2 - >8| 496| Enterococcus faecalis (vancomycin-resistant)| 0.25 - >32| 948| Enterococcus faecalis (vancomycin-resistant)| 2 - >32| 16| Enterococcus faecalis (vancomycin-resistant)| 0.25 - >512| 448| Enterococcus faecalis (vancomycin-susceptibl)| 0.25 - >4| 1130| Enterococcus faecalis (vancomycin-susceptible)| 0.06 - >512| 948| Enterococcus faecalis (vancomycin-susceptible)| 0.5 - >8| 496| Enterococcus faecalis (vancomycin-susceptible)| 0.5 - >8| 175| Enterococcus faecalis (vancomycin-susceptible)| 0.06 - >512| 448| Enterococcus faecium| ≤0.12 - >4| 1130| Enterococcus faecium| 0.5 - >32| 16| Enterococcus faecium| 0.12 - >8| 123| Enterococcus faecium| ≤0.12 - >64| 371| Enterococcus faecium| 0.25 - >128| 178| Enterococcus faecium| 2 - >128| 89| Enterococcus faecium| 0.1 - >100| 1030| Enterococcus faecium| 2 - ?| 1132| Enterococcus faecium (1 + methicillin moderately-resistant)| 8 - ?| 289| Enterococcus faecium (12311 + vancomycin-resistant)| >128 - ?| 286| Enterococcus faecium (12366 + vancomycin-resistant)| >128 - ?| 286| Enterococcus faecium (2 + methicillin moderately-resistant)| 16 - ?| 289| Enterococcus faecium (ACA-DC 3350)| 8 - ?| 910| Enterococcus faecium (ACA-DC 3359)| 16 - ?| 910| Enterococcus faecium (ATCC 19434 + vancomycin-susceptible)| 0.063 - ?| 397| Enterococcus faecium (broiler isolate)| 0.1 - >100| 1030| Enterococcus faecium (C1/17)| >16 - ?| 220| Enterococcus faecium (cattle isolate)| 0.1 - >100| 1030| Enterococcus faecium (erythromycin-resistant + vancomycin-resistant)| 2 - >512| 448| Enterococcus faecium (erythromycin-resistant + vancomycin-susceptible)| 1 - >512| 448| Enterococcus faecium (erythromycin-susceptible + vancomycin-susceptible)| 0.12 - 0.5| 448| Enterococcus faecium (KU 1778 + vancomycin-resistant)| 0.063 - ?| 397| Enterococcus faecium (MicroScan automated panel)| <0.5 - >=8| 1038| Enterococcus faecium (NCTC 7171T)| 2 - ?| 220| Enterococcus faecium (PCD 71)| 16 - ?| 910| Enterococcus faecium (PCK 38)| ≤1 - ?| 910| Enterococcus faecium (PCK 45)| ≤1 - ?| 910| Enterococcus faecium (pig isolate)| 0.1 - >100| 1030| Enterococcus faecium (van(A) E25-1)| >64 - ?| 409| Enterococcus faecium (vancomycin-resistant)| 0.25 - >4| 1130| Enterococcus faecium (vancomycin-resistant)| >4 - ?| 462| Enterococcus faecium (vancomycin-resistant)| 2 - >512| 948| Enterococcus faecium (vancomycin-resistant)| 4 - >8| 496| Enterococcus faecium (vancomycin-resistant)| >8 - ?| 175| Enterococcus faecium (vancomycin-resistant)| 2 - >16| 18| Enterococcus faecium (vancomycin-resistant)| >32 - ?| 16| Enterococcus faecium (vancomycin-susceptible)| ≤0.12 - >4| 1130| Enterococcus faecium (vancomycin-susceptible)| ≤0.5 - >4| 462| Enterococcus faecium (vancomycin-susceptible)| 0.25 - >8| 496| Enterococcus faecium (vancomycin-susceptible)| 1 - >8| 175| Enterococcus faecium (vancomycin-susceptible)| 2 - 512| 948| Enterococcus faecium (vancomycin-susceptible)| ≤0.12 - >16| 18| Enterococcus faecium (vancomycin-susceptible)| 0.12 - >512| 448| Enterococcus gallinarum| ≤0.12 - >4| 1130| Enterococcus gallinarum| ≤0.12 - >16| 18| Enterococcus gallinarum| 0.25 - >128| 178| Enterococcus gallinarum (BM 4174)| 0.25 - ?| 220| Enterococcus gallinarum (LMG 13129)| 0.5 - ?| 220| Enterococcus gallinarum (van(C))| ≤0.5 - >4| 462| Enterococcus hirae| ≤0.5 - >4| 462| Enterococcus hirae| 0.1 - >100| 1030| Enterococcus raffinosus| ≤0.12 - >4| 1130| Enterococcus raffinosus| ≤0.12 - >16| 18| Enterococcus sp. (Uraguay)| 0.5 - 4| 1391| Enterococcus spp.| ≤0.12 - >4| 1130| Enterococcus spp.| 0.12 - >8| 496| Enterococcus spp.| 0.5 - >8| 123| Enterococcus spp. (macrolide-resistant)| >128 - ?| 15| Enterococcus spp. (macrolide-susceptible)| 0.06 - 0.5| 15| Erwinia carotovora (ATCC 358)| 50 - ?| 64| Erwinia rhapontici| 5 - ?| 64| Erysipelothrix rhusiopathiae| 0.03 - ?| 488| Escherichia coli| 32 - >128| 15| Escherichia coli| 0.5 - ?| 785| Escherichia coli| 1.25 - ?| 255| Escherichia coli| 32 - ?| 733| Escherichia coli| 125 - ?| 64| Escherichia coli| >128 - ?| 1002| Escherichia coli (10)| 64 - ?| 220| Escherichia coli (14)| 128 - ?| 220| Escherichia coli (21)| 128 - ?| 220| Escherichia coli (27)| 64 - ?| 220| Escherichia coli (34)| 64 - ?| 220| Escherichia coli (43)| 64 - ?| 220| Escherichia coli (52)| >16 - ?| 220| Escherichia coli (54)| 32 - ?| 220| Escherichia coli (6)| 64 - ?| 220| Escherichia coli (ATCC 25922)| 0.3906 - ?| 1536| Escherichia coli (ATCC 25922)| >8 - ?| 650| Escherichia coli (ATCC 25922)| >64 - ?| 409| Escherichia coli (ATCC 35218)| 32 - ?| 891| Escherichia coli (BL21)| 128 - ?| 1032| Escherichia coli (C316)| ? - >128| 1023| Escherichia coli (C921-61)| 64 - ?| 955| Escherichia coli (CP78)| 0.003 - ?| 313| Escherichia coli (CP79)| 0.003 - ?| 313| Escherichia coli (DC2)| 4 - ?| 409| Escherichia coli (K-10)| 64 - ?| 955| Escherichia coli (K12 LE140)| 20.8 - ?| 1265| Escherichia coli (K-12)| 64 - ?| 955| Escherichia coli (KAM32(pHPA))| >128 - ?| 1023| Escherichia coli (KAM32(pSTV28))| 1 - ?| 1023| Escherichia coli (KAM32(pSTVqepA))| 2 - ?| 1023| Escherichia coli (KAM32(pSTVΔqepA))| 1 - ?| 1023| Escherichia coli (KAM32)| 2 - ?| 1023| Escherichia coli (KCTC 1923)| >80 - ?| 1019| Escherichia coli (MCR106)| 1 - ?| 794| Escherichia coli (O157:H7)| 17 - ?| 914| Escherichia coli (OC1555)| 530 - ?| 794| Escherichia coli (PLB3255)| 265 - ?| 794| Escherichia coli (RAM121)| 2.9 - ?| 794| Escherichia coli (RAM122)| 10.6 - ?| 794| Escherichia coli (tol(C))| 1.95 - ?| 64| Escherichia coli (TP)| >16 - ?| 220| Escherichia coli (XL2)| 32 - ?| 393| Escherichia coli (XL2)| 32 - ?| 622| Escherichia coli (XL2-66-6976-1)| 16 - ?| 622| Escherichia coli (XL2-66-6976-1)| 16 - ?| 393| Escherichia coli (XL2-66-6976-2)| 16 - ?| 393| Escherichia coli (XL2-66-6976-2)| 16 - ?| 622| Eubacterium lentum (pH 7.0)| ≤0.03 - 0.25| 818| Eubacterium lentum (pH 8.0)| ≤0.03 - 0.125| 818| Eubacterium saburreum (pH 7.0)| ≤0.03 - 0.06| 818| Eubacterium saburreum (pH 8.0)| ≤0.03 - 0.06| 818| Eubacterium spp. (pH 7.0)| ≤0.03 - 0.25| 818| Eubacterium spp. (pH 8.0)| ≤0.03 - 0.125| 818| Eubacterium timidum (pH 7.0)| ≤0.03 - 0.25| 818| Eubacterium timidum (pH 8.0)| ≤0.03 - 0.125| 818| Eubacterium yurii (pH 7.0)| ≤0.03 - 0.25| 818| Eubacterium yurii (pH 8.0)| ≤0.03 - 0.125| 818| Finegoldia magna (pH 7.0)| ≤0.03 - >32| 818| Finegoldia magna (pH 8.0)| ≤0.03 - >32| 818| Fusobacterium (penicillin-susceptible)| 0.03 - 64| 1396| Fusobacterium (penicillin-susceptible)| 8 - 64| 1396| Fusobacterium gonidiaformans| 1 - >32| 1460| Fusobacterium mortiferum| 2 - >32| 1460| Fusobacterium naviforme| 1 - >32| 1460| Fusobacterium naviforme (pH 7.0)| 0.25 - 16| 818| Fusobacterium naviforme (pH 8.0)| ≤0.03 - 8| 818| Fusobacterium necrogenes| 2 - >32| 1460| Fusobacterium necrophorum| 1 - >32| 1460| Fusobacterium necrophorum| 0.8 - 6.3| 1444| Fusobacterium necrophorum (pH 7.0)| 0.25 - 16| 818| Fusobacterium necrophorum (pH 8.0)| ≤0.03 - 8| 818| Fusobacterium nucleatum| 1 - >32| 1460| Fusobacterium nucleatum| 16 - >32| 821| Fusobacterium nucleatum (pH 7.0)| ≤0.03 - >32| 818| Fusobacterium nucleatum (pH 8.0)| ≤0.03 - 32| 818| Fusobacterium nucleatum subsp. animalis| 1 - >32| 1460| Fusobacterium russii| 1 - >32| 1460| Fusobacterium ulcerans| 2 - >32| 1460| Fusobacterium varium| 32 - >32| 1460| Gemella spp.| ≤0.12 - >16| 18| Haemolytic streptococci| 0.06 - 8| 401| Haemophilus influenzae| 0.5 - 4| 1111| Haemophilus influenzae| 0.015 - >64| 954| Haemophilus influenzae| 0.015 - >64| 1113| Haemophilus influenzae| ≤0.25 - >32| 500| Haemophilus influenzae| 1 - 32| 1113| Haemophilus influenzae| <0.01 - 64| 948| Haemophilus influenzae| 0.25 - 32| 125| Haemophilus influenzae| 1.6 - 6.3| 1413| Haemophilus influenzae| 2 - ?| 794| Haemophilus influenzae (11)| 2 - ?| 409| Haemophilus influenzae (ATCC 31517)| 4 - ?| 88| Haemophilus influenzae (ATCC 49247)| 8 - ?| 401| Haemophilus influenzae (DILL)| 8 - ?| 319| Haemophilus influenzae (ESBL)| 0.5 - >16| 19| Haemophilus influenzae (ESBL)| 0.25 - 64| 45| Haemophilus influenzae (LS-2)| 0.125 - ?| 191| Haemophilus influenzae (LS-3)| 0.125 - ?| 191| Haemophilus influenzae (NCTC 11931)| 8 - ?| 401| Haemophilus influenzae (non-ESBL)| 0.12 - >64| 195| Haemophilus influenzae (non-ESBL)| 0.12 - >64| 114| Haemophilus influenzae (non-ESBL)| 0.12 - >64| 84| Haemophilus influenzae (non-ESBL)| <0.12 - >256| 45| Haemophilus influenzae (RD-51907)| 4 - ?| 191| Haemophilus influenzae (TH13)| 0.5 - ?| 397| Haemophilus influenzae (VHIN6529)| 1 - ?| 88| Haemophilus influenzae (VHIN6536)| 2 - ?| 88| Haemophilus parasuis (Spain)| 0.25 - 8| 768| Haemophilus parasuis (UK)| 0.25 - 2| 768| Haemophilus spp.| 0.25 - 128| 401| Helicobacter pullorum| 0.25 - 4| 831| Helicobacter pylori| 0.015 - 8| 662| Helicobacter pylori| 0.05 - 0.78| 662| Helicobacter pylori| 0.1 - 0.8| 662| Helicobacter pylori| 0.39 - 0.78| 662| Helicobacter pylori| 0.5 - 1| 662| Helicobacter pylori (macrolide-resistant)| 64 - >128| 15| Helicobacter pylori (macrolide-susceptible)| 0.06 - 0.25| 15| Helicobacter pylori (pH 5.5)| 8 - ?| 658| Helicobacter pylori (pH 6.0)| 2 - ?| 658| Helicobacter pylori (pH 7.5)| 0.06 - ?| 658| Jonesia denitrificans| 0.25 - ?| 827| Klebsiella pneumonia| >16 - ?| 220| Klebsiella pneumonia (ATCC 10031)| 256 - ?| 1183| Klebsiella pneumonia (G340)| 256 - ?| 174| Klebsiella pneumonia (G595)| 128 - ?| 174| Klebsiella pneumonia (GC 7535)| 128 - ?| 174| Klebsiella pneumonia (GC 7736)| 256 - ?| 174| Klebsiella pneumonia (GC 7737)| 256 - ?| 174| Klebsiella pneumoniae (ATCC 10031)| 0.09765 - ?| 1536| Klebsiella pneumoniae (KZN)| 12.5 - ?| 1536| Lactobacillus acidophilus| 0.125 - 0.25| 878| Lactobacillus acidophilus| ≤0.125 - 0.25| 1036| Lactobacillus acidophilus (CRL 1251)| 1 - ?| 1268| Lactobacillus acidophilus (CRL 1266)| 100 - ?| 1268| Lactobacillus acidophilus (Etest)| ≤0.12 - >=256| 1036| Lactobacillus acidophilus (P/N 601379 + oxgall-stressed)| 0.98 - ?| 740| Lactobacillus acidophilus (P/N 601379 + pH 2.0)| 0.98 - ?| 740| Lactobacillus acidophilus (P/N 601379)| 0.98 - ?| 740| Lactobacillus acidophilus (R052 + oxgall-stressed)| 0.98 - ?| 740| Lactobacillus acidophilus (R052 + pH 2.0)| 0.98 - ?| 740| Lactobacillus acidophilus (R052 + pH 4.0)| 12500 - ?| 740| Lactobacillus acidophilus (R052)| 0.98 - ?| 740| Lactobacillus amylovorus (Etest)| ≤0.12 - >=256| 1036| Lactobacillus brevis| 32 - 128| 1160| Lactobacillus brevis| 0.125 - 0.25| 878| Lactobacillus buchneri| ≤0.125 - 0.25| 1036| Lactobacillus bulgaricus (P/N 601383 + oxgall-stressed)| 1.9 - ?| 740| Lactobacillus bulgaricus (P/N 601383 + pH 2.0)| 3.9 - ?| 740| Lactobacillus bulgaricus (P/N 601383 + pH 4.0)| 3.9 - ?| 740| Lactobacillus bulgaricus (P/N 601383)| 3.9 - ?| 740| Lactobacillus casei| 0.125 - 0.5| 878| Lactobacillus casei (R0215 + oxgall-stressed)| 0.98 - ?| 740| Lactobacillus casei (R0215 + pH 2.0)| 0.98 - ?| 740| Lactobacillus casei (R0215 + pH 4.0)| 3.9 - ?| 740| Lactobacillus casei (R0215)| 0.98 - ?| 740| Lactobacillus casei (R0256 + oxgall-stressed)| 0.98 - ?| 740| Lactobacillus casei (R0256 + pH 2.0)| 0.98 - ?| 740| Lactobacillus casei (R0256 + pH 4.0)| 3.9 - ?| 740| Lactobacillus casei (R0256)| 0.98 - ?| 740| Lactobacillus catenaforme (pH 7.0)| ≤0.03 - 16| 818| Lactobacillus catenaforme (pH 8.0)| ≤0.03 - 8| 818| Lactobacillus crispatus (Etest)| ≤0.12 - 0.25| 1036| Lactobacillus curvatus| 0.25 - 128| 1160| Lactobacillus curvatus| 0.125 - 0.25| 878| Lactobacillus delbrueckii| 0.125 - 0.5| 878| Lactobacillus delbrueckii (Etest)| ≤0.12 - 4| 1036| Lactobacillus delbrueckii (pH 7.0)| ≤0.03 - 16| 818| Lactobacillus delbrueckii (pH 8.0)| ≤0.03 - 8| 818| Lactobacillus fermentum| 0.125 - ?| 878| Lactobacillus fermentum (Etest)| ≤0.12 - 4| 1036| Lactobacillus gallinarum (Etest)| ≤0.12 - ?| 1036| Lactobacillus gasseri (CRL 1259)| 1 - ?| 1268| Lactobacillus gasseri (Etest)| ≤0.12 - >=256| 1036| Lactobacillus helveticus (Etest)| ≤0.12 - 0.25| 1036| Lactobacillus johnsonii (CRL 1294)| >100 - ?| 1268| Lactobacillus johnsonii (Etest)| ≤0.12 - 0.5| 1036| Lactobacillus lactis (R0187 + oxgall-stressed)| 0.98 - ?| 740| Lactobacillus lactis (R0187 + pH 2.0)| 0.98 - ?| 740| Lactobacillus lactis (R0187 + pH 4.0)| 0.98 - ?| 740| Lactobacillus lactis (R0187)| 0.98 - ?| 740| Lactobacillus oris (pH 7.0)| ≤0.03 - 16| 818| Lactobacillus oris (pH 8.0)| ≤0.03 - 8| 818| Lactobacillus paracasei| 0.25 - 1024| 1160| Lactobacillus paracasei (CRL 1289)| 100 - ?| 1268| Lactobacillus paracasei (Etest)| ≤0.12 - >=256| 1036| Lactobacillus paracasei (MDIL)| ≤0.12 - 32| 1036| Lactobacillus paracasei (P/N 601385 + oxgall-stressed)| 0.98 - ?| 740| Lactobacillus paracasei (P/N 601385 + pH 4.0)| 0.98 - ?| 740| Lactobacillus paracasei (P/N 601385)| 0.98 - ?| 740| Lactobacillus pentosus (PCD 101)| 64 - ?| 910| Lactobacillus plantarum| 0.25 - 512| 1160| Lactobacillus plantarum| 0.125 - 0.25| 878| Lactobacillus plantarum| 0.25 - 64| 1036| Lactobacillus plantarum (Etest)| ≤0.12 - 2| 1036| Lactobacillus plantarum (MDIL)| 0.25 - 1| 1036| Lactobacillus plantarum (P/N 601387 + oxgall-stressed)| 0.98 - ?| 740| Lactobacillus plantarum (P/N 601387 + pH 2.0)| 1.9 - ?| 740| Lactobacillus plantarum (P/N 601387 + pH 4.0)| 1.9 - ?| 740| Lactobacillus plantarum (P/N 601387)| 1.9 - ?| 740| Lactobacillus plantarum (pH 7.0)| ≤0.03 - 16| 818| Lactobacillus plantarum (pH 8.0)| ≤0.3 - 8| 818| Lactobacillus plantarum (R0202 + oxgall-stressed)| 0.98 - ?| 740| Lactobacillus plantarum (R0202 + pH 2.0)| 0.98 - ?| 740| Lactobacillus plantarum (R0202 + pH 4.0)| 3.9 - ?| 740| Lactobacillus plantarum (R0202)| 0.98 - ?| 740| Lactobacillus plantarum (R1078 + oxgall-stressed)| 1.9 - ?| 740| Lactobacillus plantarum (R1078 + pH 2.0)| 0.98 - ?| 740| Lactobacillus plantarum (R1078 + pH 4.0)| 3.9 - ?| 740| Lactobacillus plantarum (R1078)| 0.98 - ?| 740| Lactobacillus plantarum (R1096 + oxgall-stressed)| 0.98 - ?| 740| Lactobacillus plantarum (R1096 + pH 2.0)| 0.98 - ?| 740| Lactobacillus plantarum (R1096 + pH 4.0)| 3.9 - ?| 740| Lactobacillus plantarum (R1096)| 0.98 - ?| 740| Lactobacillus reut