SKU: E066  / 
    CAS Number: 33419-42-0


    $54.03 - $139.24
    Etoposide is an anticancer topoisomerase inhibitor that was derived from the natural product podophyllotoxin extracted from Podophyllum peltatum. It is effective against a variety of cancers, causing DNA damage which leads to apoptosis.

    Etoposide is very slightly soluble in water.
    Mechanism of ActionEtoposide targets DNA topoisomerase II, hindeirng the re-ligation step of DNA replication. This causes DNA damage and leads the cell to programmed cell death.
    ReferencesMontecucco, A., Zanetta, F., & Biamonti, G. (2015). Molecular mechanisms of etoposide. Experimental and Clinical Sciences, 14, 95-108. doi:10.17179/excli2015-561