Fervenulin, structurally related to caffeine, was first isolated from Streptomyces fervens in 1959 and reported as a broad spectrum antibiotic, with antineoplastic properties. Fervenulin inhibits egg hatch and increases juvenile mortality of the root-knot nematode Meloidogyne incognita in vitro, killing up to 100% of second-stage nematode juveniles when applied at a concentration of 250 µg/mL.
| Molecular Formula | C7H7N5O2 |
| References |
Deboer C et al (1959) Fervenulin, a new crystalline antibiotic I. Discovery and biological activities. Antibiot. Ann. 7:227 Orlov VS et al ( 1983) Free radical mechanisms of action of pyrimidotriazine antibiotics. Bioorganicheskaya Khimiya 9:556 Ruanpanum P et al (2011) Nematicidal activity of fervenulin isolated from a nematicidal actinomycete, Streptomyces sp. CMU-MH021, on Meloidogyne incognita. World J Microbiol Biotech. 27:1373 |