Fidaxomicin is the major analog of a family of macrocyclic lactones, isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow-spectrum antibiotic with excellent activity against Gram-positive bacteria, notably Clostridium difficile.
Fidaxomicin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
