SKU: F025  / 
    CAS Number: 873857-62-6

    Fidaxomicin

    $89.25 - $152.25

    Fidaxomicin is the major analog of a family of macrocyclic lactones, isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow-spectrum antibiotic with excellent activity against Gram-positive bacteria, notably Clostridium difficile

    Fidaxomicin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    Molecular Formula C52H74Cl2O18
    Spectrum Fidaxomicin is a narrow-spectrum antibiotic with excellent activity against Gram-positive bacteria, notably Clostridium difficile.
    Microbiology Applications Clostridium difficile (CDI) is the major cause of nosocomial infection, and new antimicrobials like Fidaxomicin that do not alter normal gut flora are being explored (Mullane and Gorbach, 2014).
    References

    Mullane KM and Gorbach S (2011) Fidaxomicin: First-in-class macrocyclic antibiotic. Expert Rev. Anti-infective Ther. 9 (70):767-777  PMID 21810048 

    Omura S et al (1986)  Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physico-chemical and biological properties. J. Antibiot. (Tokyo) 39(10):1407-1412

    Parenti F et al (1975)  Lipiarmycin, a new antibiotic from Actinoplanes. I. Description of the producer strain and fermentation studies. J. Antibiot. 28:247

    Theriault RJ et al (1987)  Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I.Taxonomy, fermentation and antibacterial activity. J. Antibiot. 140:567