Fidaxomicin is the major analog of a family of macrocyclic lactones, isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow-spectrum antibiotic with excellent activity against Gram-positive bacteria, notably Clostridium difficile.
Fidaxomicin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
|Spectrum||Fidaxomicin is a narrow-spectrum antibiotic with excellent activity against Gram-positive bacteria, notably Clostridium difficile.|
|Microbiology Applications||Clostridium difficile (CDI) is the major cause of nosocomial infection, and new antimicrobials like Fidaxomicin that do not alter normal gut flora are being explored (Mullane and Gorbach, 2014).|
S (2011) Fidaxomicin: First-in-class macrocyclic antibiotic. Expert Rev. Anti-infective Ther. 9 (70):767-777 PMID 21810048
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