FR 179642 is a member of the echinocandin antifungal family patented in 1991 by Ueda and colleagues at Fujisawa, now
Astellas Pharma. FR 179642 is formed by the selective hydrolysis of FR 901379 using a cyclic lipopeptide acylase found in
<0.1% of soil microbes, notably three undescribed Streptomyces and two fungi. Like all echocandins, FR 179642 inhibits the synthesis of 1,3-β-D-glucan in the fungal cell wall. FR 179642 is an important pharmaceutical intermediate for production of the commercial antifungal, micafungin.
Tomishima M et al (2008) Novel echinocandin antifungals. Part 1: Novel side-chain analogs of the natural product FR901379. Bioorg. Med. Chem. Letters 18:1474
Toshiro I et al (1991) Preparation of cyclic peptide (echinocandin B) antibiotics. Eur. Pat. Appl. EP 462531 A2
Ueda S et al (1992) Screening and characterization of microorganisms with FR 901379 acylase activity. J. Anti biot. 63:65