SKU: F029  / 
    CAS Number: 23110-15-8

    Fumagillin

    $142.23 - $497.81
    Fumagillin is a polyene mycotoxin isolated from Aspergillus fumigatus in 1951 as a potent antiprotozoan for the treatment of amoebiasis. More recently, fumagillin has been shown to inhibit endothelial cell proliferation and angiogenesis.

    Fumagillin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
    Mechanism of ActionFumagillin inhibits endothelial cell proliferation and angiogenesis by inhibiting methionine aminopeptidase-2 (MetAP-2).
    ReferencesFumagillin (H-3), a new antibiotic with amebicidal properties. McCowen M. C. et al. Science 1951, 23, 202.

    Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2. Griffith E. C. et al. PNAS 1998, 95, 15183.

    Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors. Lefkove B. et al. Expert Rev. Anti Infect. Ther. 2007, 5, 573.