Fumonisin B1 is a major analogue of a family of potent mycotoxins produced by various Fusarium species, associated with animal toxicity worldwide. In vitro, fumonisin B1 inhibits sphingosine N-acyl-transferase (ceramide synthase) and blocks the growth of axons.
Fumonisin B1 is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Fumonisin B1 is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| References | Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme. Bezuidenhout S. C. et al. J. Chem. Soc. Chem. Commun. 1988, 743. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. Wang E. et al. J. Biol. Chem. 1991, 266, 14486. Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons. Harel R. & Futerman A. H. J. Biol. Chem. 1993, 268, 14476. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. Merrill A. H. et al. J. Biol. Chem. 1993, 268, 27299. |
