Hecogenin Acetate is a steroidal saponin first published in 1943 by Marker and colleagues at Penn State University and isolated from Agave. Hecogenin Acetate induces cell cycle arrest and senescence, and modulates ERK1/2 phosphorylation and MMP-2 production. Hecogenin Acetate has nociceptive activity mediated by opioid receptors and endogenous analgesic mechanisms.