Hecogenin Acetate is a steroidal saponin first published in 1943 by Marker and colleagues at Penn State University and isolated from Agave. Hecogenin Acetate induces cell cycle arrest and senescence, and modulates ERK1/2 phosphorylation and MMP-2 production. Hecogenin Acetate has nociceptive activity mediated by opioid receptors and endogenous analgesic mechanisms.
| Molecular Formula | C29H44O5 |
| References |
Gama KB et al (2013) Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. J. Nat. Prod. 76 (4):559 Gasparotto J et al (2014) Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line. Anticancer Agents Med. Chem. 14:1128 Marker RE et al (1943) Sterols. CLVII. Sapogenins. 69. Isolation and structures of thirteen new steroidal sapogenins. New sources for known sapogenins. J. Am.Chem. Soc. 165:1199 |
