Pexiganan is an antimicrobial peptide (AMP) that is effective against a broad spectrum of bacteria including aerobic and anaerobic, gram-positive and gram-negative. Bacterial resistance to pexiganan is very unlikely to develop.
|Mechanism of Action||Pexiganan adopts a helix form in the cell membrane, causing pores in the membrane and leakage leading to cell death.|
|References||Gottler, L. M., & Ramamoorthy, A. (2009). Structure, membrane orientation, mechanism, and function of pexiganan — A highly potent antimicrobial peptide designed from magainin. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1788(8), 1680–1686. doi:10.1016/j.bbamem.2008.10.009|