SKU: H048  / 
    CAS Number: C22H35NO2

    Himbacine

    $185.22 - $648.27

    Himbacine is a piperidine alkaloid with a tricyclic lactone scaffold isolated from Galbulimima sp. (Himantandra sp.) by Ritchie and Taylor, University of Sydney, Australia in 1956. Himbacine is a potent M2 muscarinic receptor antagonist with selectivity for cardiac receptors and a thrombin (PAR1) receptor inhibitor.  Its analog, vorapaxar is marketed for secondary prevention of thrombotic cardiovascular events.

    Molecular Formula  C22H35NO
    References

    Anwar-ul S et al (1986)  The cardio-selectivity of himbacine: a muscarine receptor antagonist. ., Naunyn Schmiedebergs Arch. Pharmacol. 332:16

    Brown FFC et al (1956)  The chemical constituents of Himantandra species. II. The isolation of the alkaloids of Himantandra baccata Bail. and H. belgraveana F .Muell. Aust. J. Chem. 9:283

    Chackalamannil S et al (2008)  Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity. J. Med. Chem. 51:3061

    Darroch SA et al (1990)  Structure-activity relationships of some Galbulimima alkaloids related to himbacine. Eur. J. Pharmacol. 182:131

    Mander LN et al (1967)  The chemical constituents of Galbulimima species IX. The structures of himbadine and alkaloid G.B. 13. Aust. J. Chem. 20:1473

    Willis AC et al (2006)  The absolute stereochemistry of the Galbulimima alkaloids. Aust. J. Chem. 59:629