Hydroxyurea is an antineoplastic chemotherapeutic compound used in sickle cell anemia studies and cancer research, including leukemia, skin cancer, and ovarian cancers.
Hydroxyurea is freely soluble in water.
| Mechanism of Action | Hydroxyurea targets the ribonucleotide reductase essential to DNA synthesis, and arrests the cell cycle at S-phase. |
| References | Segal JB, Strouse JJ, Beach MC, et al. Hydroxyurea for the Treatment of Sickle Cell Disease. Rockville (MD): Agency for Healthcare Research and Quality (US); 2008 Feb. (Evidence Reports/Technology Assessments, No. 165.) 1, Introduction. Available from: http://www.ncbi.nlm.nih.gov/books/NBK38503/ |