Indolmycin is a highly selective antibiotic which acts as a tryptophan anti-metabolite. Recent research has shown that indolmycin is active against Mycobacteria and H. pylori, and can stimulate transcription in Escherichia coli.
Indolmycin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Indolmycin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| Molecular Formula | C14H15N3O2 |
| References | Indolmycin resistance of Streptomyces coelicolor A3(2) by induced expression of one of its two tryptophanyl-tRNA synthetases. Kitabatake M. et al. J Biol Chem. 2002, 277, 23882. Indolmycin-mediated inhibition and stimulation of transcription at the trp promoter of Escherichia coli. Bogosian G. et al. J Bacteriol. 1983, 153, 1120. Development of a stereoselective practical synthetic route to indolmycin, a candidate anti-H. pylori agent. Hasuoka A. et al. Chem Pharm. Bull. 2001, 49, 1604. |